Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.61 |
| ▸ | HPN | P05981 | 2/20 | 0.56 |
| ▸ | PLAU | P00749 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1000637 | 0.90 | HDAC1 (0.58) | HDAC1HPNPLAUHDAC8HDAC6 | |
| SCHEMBL4459748 | 0.83 | HDAC1 (0.68) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL1001467 | 0.83 | HDAC1 (0.68) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL1884950 | 0.79 | HDAC1 (0.78) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL3505877 | 0.79 | MMP9 (0.55) | HDAC1HPNPLAUMAPT | |
| SCHEMBL8258861 | 0.79 | MMP9 (0.55) | HDAC1HPNPLAUMAPT | |
| SCHEMBL1891537 | 0.78 | HDAC1 (0.74) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL1884523 | 0.78 | HDAC1 (0.73) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL8260193 | 0.76 | HDAC1 (0.62) | HDAC1 | |
| SCHEMBL1883963 | 0.76 | HDAC1 (1.00) | HDAC1HDAC8HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872024-B2 | Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions | MERCK SHARP & DOHME CORP. (US) | 2011-01-18 | — | — | US | claimed |
| US-20090318541-A1 | Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions | MERCK SHARP & DOHME LLC | 2009-12-24 | — | — | US | claimed |
| EP-1874294-A1 | BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES WITH CARBAMATE, UREA, AMIDE AND SULFONAMIDE SUBSTITUTIONS | Merck & Co., Inc. (US) | 2008-01-09 | — | — | EP | claimed |
| WO-2006115833-A1 | BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES WITH CARBAMATE, UREA, AMIDE AND SULFONAMIDE SUBSTITUTIONS | MERCK & CO., INC. (US) | 2006-11-02 | — | — | WO | claimed |
| US-7872024-B2 | Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions | MERCK SHARP & DOHME CORP. (US) | 2011-01-18 | — | — | US | disclosed |
| US-7872024-B2 | Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions | MERCK SHARP & DOHME CORP. (US) | 2011-01-18 | — | — | US | disclosed |
| US-7872024-B2 | Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions | MERCK SHARP & DOHME CORP. (US) | 2011-01-18 | — | — | US | disclosed |
| US-20090318541-A1 | Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions | MERCK SHARP & DOHME LLC | 2009-12-24 | — | — | US | disclosed |
| US-20090318541-A1 | Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions | MERCK SHARP & DOHME LLC | 2009-12-24 | — | — | US | disclosed |
| US-20090318541-A1 | Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions | MERCK SHARP & DOHME LLC | 2009-12-24 | — | — | US | disclosed |
| EP-1874294-A1 | BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES WITH CARBAMATE, UREA, AMIDE AND SULFONAMIDE SUBSTITUTIONS | Merck & Co., Inc. (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006115833-A1 | BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES WITH CARBAMATE, UREA, AMIDE AND SULFONAMIDE SUBSTITUTIONS | MERCK & CO., INC. (US) | 2006-11-02 | — | — | WO | disclosed |
| WO-2006115833-A1 | BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES WITH CARBAMATE, UREA, AMIDE AND SULFONAMIDE SUBSTITUTIONS | MERCK & CO., INC. (US) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318541-A1 | Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions | HDAC5, HAT1, BRDT | HDAC1 4/4885HPN 441/4885PLAU 3343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.