Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 3/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | HAO1 | Q9UJM8 | 4/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4466659 | 0.88 | FFAR4 (0.50) | LMNATDP1GRM5FFAR4CHRNB2 | |
| SCHEMBL4458288 | 0.86 | FFAR4 (0.53) | LMNATDP1GRM5FFAR4HAO1 | |
| SCHEMBL4465810 | 0.85 | CYP19A1 (0.47) | LMNATDP1GRM5FFAR4CHRNB2 | |
| SCHEMBL4462299 | 0.85 | HAO1 (0.55) | LMNATDP1GRM5FFAR4HAO1 | |
| SCHEMBL4456183 | 0.82 | FFAR4 (0.47) | LMNATDP1GRM5FFAR4HAO1 | |
| SCHEMBL13989096 | 0.81 | FFAR4 (0.48) | LMNATDP1GRM5FFAR4HAO1 | |
| SCHEMBL4465817 | 0.81 | CYP19A1 (0.57) | LMNATDP1GRM5FFAR4HAO1 | |
| Hydrochloric Acid SCHEMBL4861873 | 0.80 | FFAR4 (0.47) | LMNATDP1GRM5FFAR4HAO1 | |
| SCHEMBL4454767 | 0.80 | CYP19A1 (0.63) | LMNATDP1GRM5FFAR4HAO1 | |
| SCHEMBL13606109 | 0.79 | LMNA (0.50) | LMNATDP1GRM5FFAR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306115-A1 | Phenyl ethyne compounds | MERCK SHARP & DOHME CORP. | 2009-12-10 | — | — | US | disclosed |
| US-20090306115-A1 | Phenyl ethyne compounds | MERCK SHARP & DOHME CORP. | 2009-12-10 | — | — | US | disclosed |
| EP-1874724-A2 | PHENYL ETHYNE COMPOUNDS | Merck & Co., Inc. (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006115895-A2 | PHENYL ETHYNE COMPOUNDS | MERCK & CO., INC. (US) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306115-A1 | Phenyl ethyne compounds | DDT, CHRM3, CBR3 | LMNA 4450/4885TDP1 3721/4885GRM5 143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.