Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | GSR | P00390 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26638056 | 0.88 | ALDH1A1 (0.63) | ALDH1A1BLMPMP22MEN1ABCB11 | |
| SCHEMBL25860578 | 0.76 | ALDH1A1 (0.40) | ALDH1A1BLMPMP22MEN1ABCB11 | |
| SCHEMBL11179608 | 0.69 | ALDH1A1 (0.59) | ALDH1A1BLMPMP22MEN1ABCB11 | |
| SCHEMBL11198641 | 0.68 | ALDH1A1 (0.63) | ALDH1A1BLMPMP22MEN1ABCB11 | |
| SCHEMBL25763748 | 0.68 | ALDH1A1 (0.58) | ALDH1A1BLMPMP22MEN1ABCB11 | |
| SCHEMBL19351409 | 0.67 | ALDH1A1 (0.77) | ALDH1A1BLMPMP22MEN1ABCB11 | |
| SCHEMBL10005923 | 0.67 | ALDH1A1 (0.77) | ALDH1A1BLMPMP22MEN1ABCB11 | |
| Carmustine SCHEMBL2047318 | 0.67 | ALDH1A1 (1.00) | ALDH1A1BLMPMP22MEN1ABCB11 | |
| Carmustine SCHEMBL4503 | 0.67 | ALDH1A1 (1.00) | ALDH1A1BLMPMP22MEN1ABCB11 | |
| SCHEMBL11195747 | 0.66 | ALDH1A1 (0.54) | ALDH1A1BLMPMP22MEN1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602499-B1 | Viral mutants for selectively killing neoplastic cells; herpes simplex virus vector; transgene encoding cytochrome P450, chemotherapeutic agent activated by cytochrome P450; viral mediated oncolysis and anticancer \"suicide\" gene therapy | THE GENERAL HOSPITAL CORPORATION | 2003-08-05 | — | — | US | claimed |
| EP-1073442-A1 | COMBINATION VIRAL-BASED AND GENE-BASED THERAPY OF TUMORS | THE GENERAL HOSPITAL CORPORATION (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999055345-A9 | COMBINATION VIRAL-BASED AND GENE-BASED THERAPY OF TUMORS | GEN HOSPITAL CORP (US) | 2000-04-13 | — | — | WO | claimed |
| WO-1999055345-A1 | COMBINATION VIRAL-BASED AND GENE-BASED THERAPY OF TUMORS | THE GENERAL HOSPITAL CORPORATION (US) | 1999-11-04 | — | — | WO | claimed |
| US-7514252-B2 | Cell-specific and/or tumor-specific promoter retargeting of herpes γ 34.5 gene expression | THE GENERAL HOSPITAL CORPORATION (US) | 2009-04-07 | — | — | US | disclosed |
| US-20050163758-A1 | Cell-specific and/or tumor-specific promoter retargeting of herpes gamma 34.5 gene expression | THE GENERAL HOSPITAL CORPORATION | 2005-07-28 | — | — | US | disclosed |
| US-6897057-B1 | Cell-specific and/or tumor-specific promoter retargeting of herpes γ 34.5 gene expression | THE GENERAL HOSPITAL CORPORATION (US) | 2005-05-24 | — | — | US | disclosed |
| EP-1212428-B1 | CELL-SPECIFIC AND/OR TUMOR-SPECIFIC PROMOTER RETARGETING OF HERPES GAMMA 34.5 GENE EXPRESSION | GEN HOSPITAL CORP (US) | 2004-12-01 | — | — | EP | disclosed |
| US-6602499-B1 | Viral mutants for selectively killing neoplastic cells; herpes simplex virus vector; transgene encoding cytochrome P450, chemotherapeutic agent activated by cytochrome P450; viral mediated oncolysis and anticancer \"suicide\" gene therapy | THE GENERAL HOSPITAL CORPORATION | 2003-08-05 | — | — | US | disclosed |
| EP-1212428-A1 | CELL-SPECIFIC AND/OR TUMOR-SPECIFIC PROMOTER RETARGETING OF HERPES GAMMA 34.5 GENE EXPRESSION | THE GENERAL HOSPITAL CORPORATION (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016331-A1 | CELL-SPECIFIC AND/OR TUMOR-SPECIFIC PROMOTER RETARGETING OF HERPES GAMMA 34.5 GENE EXPRESSION | THE GENERAL HOSPITAL CORPORATION (US) | 2001-03-08 | — | — | WO | disclosed |
| EP-1073442-A1 | COMBINATION VIRAL-BASED AND GENE-BASED THERAPY OF TUMORS | THE GENERAL HOSPITAL CORPORATION (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-2000029033-A2 | A METHOD OF GENETIC VECTOR DELIVERY | THE GENERAL HOSPITAL CORPORATION (US) | 2000-05-25 | — | — | WO | disclosed |
| WO-1999055345-A9 | COMBINATION VIRAL-BASED AND GENE-BASED THERAPY OF TUMORS | GEN HOSPITAL CORP (US) | 2000-04-13 | — | — | WO | disclosed |
| WO-1999055345-A1 | COMBINATION VIRAL-BASED AND GENE-BASED THERAPY OF TUMORS | THE GENERAL HOSPITAL CORPORATION (US) | 1999-11-04 | — | — | WO | disclosed |