Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4467510 | 0.85 | FFAR1 (0.50) | FFAR1 | |
| SCHEMBL27722556 | 0.85 | LOXL2 (0.44) | FFAR1GRM5 | |
| SCHEMBL4454587 | 0.84 | HAO1 (0.48) | HAO1GRM5 | |
| SCHEMBL4456181 | 0.82 | CA12 (0.49) | GRM5 | |
| SCHEMBL29478750 | 0.80 | GLA (0.50) | FFAR1 | |
| SCHEMBL92972 | 0.80 | GLA (0.50) | FFAR1 | |
| SCHEMBL4458314 | 0.80 | HAO1 (0.44) | HAO1GRM5 | |
| SCHEMBL1477171 | 0.79 | FFAR1 (0.46) | FFAR1GRM5 | |
| SCHEMBL13605867 | 0.79 | PRKCI (0.45) | GRM5 | |
| Bromide SCHEMBL29784624 | 0.78 | GLA (0.49) | FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306115-A1 | Phenyl ethyne compounds | MERCK SHARP & DOHME CORP. | 2009-12-10 | — | — | US | disclosed |
| US-20090306115-A1 | Phenyl ethyne compounds | MERCK SHARP & DOHME CORP. | 2009-12-10 | — | — | US | disclosed |
| CN-101163667-A | Phenylacetylene compounds | MERCK & CO INC (US) | 2008-04-16 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306115-A1 | Phenyl ethyne compounds | DDT, CHRM3, CBR3 | FFAR1 934/4885HAO1 3171/4885GRM5 143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.