Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.61 |
| ▸ | JAK3 | P52333 | 2/20 | 0.61 |
| ▸ | IKBKB | O14920 | 5/20 | 0.58 |
| ▸ | CHUK | O15111 | 4/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.52 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4769001 | 0.88 | IKBKB (0.53) | JAK2JAK3IKBKBCHUKHDAC6 | |
| SCHEMBL4380256 | 0.82 | JAK2 (0.65) | JAK2JAK3IKBKBCHUKHDAC6 | |
| SCHEMBL4378143 | 0.79 | JAK2 (0.90) | JAK2JAK3IKBKBCHUKHDAC6 | |
| SCHEMBL4380673 | 0.79 | JAK2 (0.76) | JAK2JAK3IKBKBCHUKHDAC6 | |
| SCHEMBL3753598 | 0.78 | IKBKB (0.65) | JAK2JAK3IKBKBCHUKHDAC6 | |
| SCHEMBL4383820 | 0.77 | JAK2 (1.00) | JAK2JAK3IKBKBHDAC6HDAC1 | |
| SCHEMBL4583756 | 0.77 | JAK2 (0.57) | JAK2JAK3IKBKBCHUKHDAC6 | |
| SCHEMBL4374711 | 0.77 | JAK2 (0.72) | JAK2JAK3IKBKBCHUKHDAC6 | |
| SCHEMBL4382381 | 0.77 | JAK2 (0.81) | JAK2JAK3IKBKBCHUK | |
| SCHEMBL4380255 | 0.76 | IKBKB (0.71) | JAK2JAK3IKBKBCHUKHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |