Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.57 |
| ▸ | JAK3 | P52333 | 2/20 | 0.57 |
| ▸ | IKBKB | O14920 | 2/20 | 0.53 |
| ▸ | CHUK | O15111 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.51 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583759 | 0.80 | JAK2 (0.56) | JAK2JAK3IKBKBCHUKHDAC1 | |
| SCHEMBL4380256 | 0.78 | JAK2 (0.65) | JAK2JAK3IKBKBCHUKHDAC1 | |
| SCHEMBL4376724 | 0.78 | JAK2 (0.82) | JAK2JAK3IKBKBCHUKHDAC1 | |
| SCHEMBL4381980 | 0.77 | JAK2 (0.74) | JAK2JAK3IKBKBHDAC1HDAC6 | |
| SCHEMBL4462282 | 0.77 | JAK2 (0.61) | JAK2JAK3IKBKBCHUKHDAC1 | |
| SCHEMBL25216750 | 0.76 | SRC (0.42) | — | |
| SCHEMBL30086516 | 0.76 | SRC (0.42) | — | |
| SCHEMBL8084736 | 0.76 | JAK2 (0.76) | JAK2JAK3IKBKBHDAC1HDAC6 | |
| SCHEMBL8084292 | 0.75 | JAK2 (0.67) | JAK2JAK3HDAC1HDAC6PLK1 | |
| SCHEMBL3753598 | 0.75 | IKBKB (0.65) | JAK2JAK3IKBKBCHUKHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |
| EP-1979329-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |