Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4462345 | 1.00 | TSHR (0.63) | TSHRALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL4463700 | 0.88 | ALDH1A1 (0.65) | TSHRALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL4463694 | 0.88 | ALDH1A1 (0.65) | TSHRALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL14375767 | 0.79 | TSHR (0.70) | TSHRALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL4462340 | 0.78 | ALDH1A1 (0.83) | TSHRALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL4462337 | 0.78 | ALDH1A1 (0.83) | TSHRALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL16704291 | 0.74 | FFAR1 (0.47) | TSHRALDH1A1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL18319565 | 0.74 | FFAR1 (0.47) | TSHRALDH1A1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL14424868 | 0.72 | POLB (0.71) | TSHRALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL14990216 | 0.72 | ALDH1A1 (0.65) | TSHRALDH1A1SMN1; SMN2KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230204593-A1 | MICROVESICLE HISTONE H2AX AS A BIOMARKER FOR GENOTOXIC STRESS | PIOMA, INC. | 2023-06-29 | — | — | US | disclosed |
| US-11513125-B2 | Microvesicle histone H2AX as a biomarker for genotoxic stress | PIOMA, INC. (US) | 2022-11-29 | — | — | US | disclosed |
| EP-2971282-B1 | MICROVESICLE HISTONE H2AX AS A BIOMARKER FOR GENOTOXIC STRESS | PIOMA INC (US) | 2018-09-19 | — | — | EP | disclosed |
| US-20160041175-A1 | MICROVESICLE HISTONE H2AX AS A BIOMARKER FOR GENOTOXIC STRESS | PIOMA, INC. | 2016-02-11 | — | — | US | disclosed |
| EP-2971282-A1 | MICROVESICLE HISTONE H2AX AS A BIOMARKER FOR GENOTOXIC STRESS | Pioma Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014152873-A1 | MICROVESICLE HISTONE H2AX AS A BIOMARKER FOR GENOTOXIC STRESS | PIOMA INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| EP-2050452-A1 | indenoisoquinolines as topoisomerase inhibitors I useful as antineoplastic agents | Purdue Research Foundation (US) | 2009-04-22 | — | — | EP | disclosed |
| US-6509344-B1 | A method for treating a patient having cancer, said method comprising the step of administering to the patient an effective amount of a compound according to claim 1, whereupon said patient is treated for cancer, and wherein the cancer is | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2003-01-21 | — | — | US | disclosed |
| EP-1123099-A4 | NOVEL INDENOISOQUINOLINES AS ANTINEOPLASTIC AGENTS | PURDUE RESEARCH FOUNDATION (US) | 2002-08-21 | — | — | EP | disclosed |
| EP-1123099-A1 | NOVEL INDENOISOQUINOLINES AS ANTINEOPLASTIC AGENTS | PURDUE RESEARCH FOUNDATION (US) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000021537-A1 | NOVEL INDENOISOQUINOLINES AS ANTINEOPLASTIC AGENTS | PURDUE RESEARCH FOUNDATION (US) | 2000-04-20 | — | — | WO | disclosed |