Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18381213 | 0.89 | CYP3A4 (0.60) | HDAC8HDAC2HDAC6MEN1KMT2A | |
| SCHEMBL16610103 | 0.87 | CYP3A4 (0.61) | HDAC8HDAC2HDAC6MEN1KMT2A | |
| SCHEMBL18381201 | 0.85 | CYP3A4 (0.67) | HDAC8HDAC2HDAC6MEN1KMT2A | |
| SCHEMBL12313357 | 0.84 | HDAC2 (0.56) | HDAC8HDAC2HDAC6MEN1KMT2A | |
| SCHEMBL2755854 | 0.84 | RECQL (0.71) | HDAC8HDAC2HDAC6MEN1KMT2A | |
| SCHEMBL1274303 | 0.84 | RECQL (0.71) | KMT2ASMN1; SMN2CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL25784651 | 0.83 | HDAC2 (0.61) | HDAC8HDAC2HDAC6MEN1KMT2A | |
| SCHEMBL3558312 | 0.82 | MEN1 (0.63) | HDAC8HDAC2HDAC6MEN1KMT2A | |
| SCHEMBL30208757 | 0.82 | MEN1 (0.63) | HDAC8HDAC2HDAC6MEN1KMT2A | |
| SCHEMBL16353647 | 0.82 | TBXAS1 (0.61) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | claimed |