SCHEMBL4462679

SCHEMBL4462679

Cc1nc(Cl)cc(Nc2ncc(C(=O)Nc3cccc(Cl)c3Cl)s2)n1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LCK P06239 13/20 0.64
ABL1 P00519 7/20 0.64
SRC P12931 5/20 0.64
BCR P11274 4/20 0.64
EGFR P00533 3/20 0.64
FYN P06241 3/20 0.64
YES1 P07947 3/20 0.64
LYN P07948 3/20 0.64
HCK P08631 3/20 0.64
KIT P10721 3/20 0.64
MAPK14 Q16539 3/20 0.64
MAPK13 O15264 2/20 0.64
ERBB2 P04626 2/20 0.64
FGR P09769 2/20 0.64
JAK3 P52333 2/20 0.64
MAPK12 P53778 2/20 0.64
MAPK11 Q15759 2/20 0.64
PKMYT1 Q99640 3/20 0.57
RAB9A P51151 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20785959 0.92 PKMYT1 (0.66) LCKABL1SRCBCREGFR
SCHEMBL1704860 0.89 LCK (0.76) LCKABL1SRCBCREGFR
SCHEMBL28371011 0.88 LCK (0.63) LCKABL1SRCBCREGFR
SCHEMBL21875005 0.86 ABL1 (0.64) LCKABL1SRCBCREGFR
SCHEMBL1146860 0.86 LCK (0.85) LCKABL1SRCBCREGFR
SCHEMBL29355730 0.86 LCK (0.85) LCKABL1SRCBCREGFR
SCHEMBL20633284 0.85 LCK (0.76) LCKABL1SRCBCREGFR
SCHEMBL22964561 0.83 LCK (0.60) LCKABL1SRCBCREGFR
SCHEMBL4463117 0.83 LCK (0.68) LCKABL1SRCBCREGFR
SCHEMBL4233014 0.83 LCK (0.76) LCKABL1SRCBCREGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2109690-A1 NOVEL TISSUE PROTECTIVE ERYTHROPOIETIN RECEPTOR (NEPOR) AND METHODS OF USE Alepor GMBH & CO. KG (DE) 2009-10-21 EP disclosed
WO-2009068677-A1 NOVEL TISSUE PROTECTIVE ERYTHROPOIETIN RECEPTOR (NEPOR) AND METHODS OF USE ALEPOR GMBH & CO. KG (DE) 2009-06-04 WO disclosed