Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4795499 | 0.73 | TRPA1 (0.50) | TRPA1 | |
| SCHEMBL4795502 | 0.73 | TRPA1 (0.50) | TRPA1 | |
| Hydrochloric Acid SCHEMBL8007872 | 0.72 | TRPA1 (0.48) | TRPA1 | |
| Hydrochloric Acid SCHEMBL8007871 | 0.72 | TRPA1 (0.48) | TRPA1 | |
| SCHEMBL29633894 | 0.69 | — | — | |
| SCHEMBL9926021 | 0.69 | TRPA1 (0.58) | TRPA1 | |
| SCHEMBL15075855 | 0.69 | — | — | |
| SCHEMBL5050147 | 0.69 | TRPA1 (0.58) | TRPA1 | |
| SCHEMBL30691872 | 0.69 | TRPA1 (0.58) | TRPA1 | |
| SCHEMBL9926022 | 0.64 | TRPA1 (0.58) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090291941-A1 | Tyrosine Kinase Inhibitors | MERCK SHARP & DOHME CORP. | 2009-11-26 | — | — | US | disclosed |
| US-20090291941-A1 | Tyrosine Kinase Inhibitors | MERCK SHARP & DOHME CORP. | 2009-11-26 | — | — | US | disclosed |
| EP-1951249-A2 | TYROSINE KINASE INHIBITORS | Merck and Co., Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| EP-1951249-A2 | TYROSINE KINASE INHIBITORS | Merck and Co., Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007050401-A3 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2007-11-15 | — | — | WO | disclosed |
| WO-2007050401-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | disclosed |
| WO-2007050401-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291941-A1 | Tyrosine Kinase Inhibitors | ABL1, ERBB2, RET | TRPA1 4139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.