Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | IKBKB | O14920 | 6/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | ACHE | P22303 | 4/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | MIF | P14174 | 2/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 2/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | AKT1 | P31749 | 2/20 | 0.47 |
| ▸ | AKT2 | P31751 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463213 | 1.00 | KMT2A (1.00) | KMT2AMEN1IKBKBCYP1A2ACHE | |
| SCHEMBL14820391 | 1.00 | KMT2A (1.00) | KMT2AMEN1IKBKBCYP1A2ACHE | |
| Hydrochloric Acid SCHEMBL15872122 | 0.98 | KMT2A (0.96) | KMT2AMEN1IKBKBCYP1A2ACHE | |
| Hydrochloric Acid SCHEMBL29493044 | 0.98 | KMT2A (0.96) | KMT2AMEN1IKBKBCYP1A2ACHE | |
| Hydrochloric Acid SCHEMBL15872121 | 0.98 | KMT2A (0.96) | KMT2AMEN1IKBKBCYP1A2ACHE | |
| SCHEMBL23923069 | 0.83 | CYP1A2 (0.85) | KMT2AMEN1CYP1A2ACHEPTGS2 | |
| SCHEMBL14017013 | 0.83 | CYP1A2 (0.85) | KMT2AMEN1CYP1A2ACHEPTGS2 | |
| SCHEMBL932826 | 0.80 | IKBKB (1.00) | KMT2AMEN1IKBKBCYP1A2ACHE | |
| SCHEMBL11482541 | 0.80 | CYP1A2 (1.00) | KMT2AMEN1CYP1A2ACHEBCHE | |
| SCHEMBL21166873 | 0.80 | IKBKB (0.67) | KMT2AMEN1IKBKBCYP1A2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582655-B2 | 1-[4-(2-Dimethylaminoethoxy)phenylcarbonyl]-3,5-bis(phenylmethylene)-4-piperidone hydrochloride; useful in reversing multidrug resistance | UNIVERSITY OF SASKATCHEWAN (CA) | 2009-09-01 | — | — | US | disclosed |
| EP-1960358-A1 | ANTINEOPLASTIC COMPOUNDS | University of Saskatchewan (CA) | 2008-08-27 | — | — | EP | disclosed |
| US-20070155733-A1 | 1-[4-(2-Dimethylaminoethoxy)phenylcarbonyl]-3,5-bis(phenylmethylene)-4-piperidone hydrochloride; useful in reversing multidrug resistance | UNIVERSITY OF SASKATCHEWAN (CA) | 2007-07-05 | — | — | US | disclosed |
| WO-2007059613-A1 | ANTINEOPLASTIC COMPOUNDS | UNIVERSITY OF SASKATCHEWAN (CA) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155733-A1 | 1-[4-(2-Dimethylaminoethoxy)phenylcarbonyl]-3,5-bis(phenylmethylene)-4-piperidone hydrochloride; useful in reversing multidrug resistance | ABCC1, MCL1, SLC11A2 | KMT2A 1855/4885MEN1 3367/4885IKBKB 253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.