Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 0.53 |
| ▸ | GOPC | Q9HD26 | 2/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KCNA5 | P22460 | 10/20 | 0.47 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4458259 | 0.98 | CFTR (0.55) | CFTRGOPCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4459337 | 0.98 | CFTR (0.55) | CFTRGOPCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4464202 | 0.94 | CFTR (0.59) | CFTRGOPCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4462106 | 0.94 | CFTR (0.53) | CFTRGOPCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14435411 | 0.93 | CFTR (0.50) | CFTRGOPCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4465855 | 0.85 | KCNA5 (0.41) | CFTRGOPCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4453037 | 0.82 | KCNA5 (0.40) | CFTRGOPCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4464162 | 0.81 | KCNA5 (0.48) | CFTRGOPCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4461885 | 0.81 | CYP19A1 (0.59) | CFTRGOPCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4461908 | 0.81 | CYP19A1 (0.63) | CFTRGOPCSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090030043-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-01-29 | — | — | US | claimed |
| EP-1981507-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2008-10-22 | — | — | EP | claimed |
| WO-2007089679-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | claimed |
| US-20090030043-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-01-29 | — | — | US | disclosed |
| EP-1981507-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007089679-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030043-A1 | Potassium Channel Inhibitors | KCNJ2, KCNH2, KCNH3 | CFTR 520/4885GOPC 2527/4885SLC6A2 254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.