Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.57 |
| ▸ | ABL1 | P00519 | 2/20 | 0.54 |
| ▸ | RAF1 | P04049 | 2/20 | 0.54 |
| ▸ | LYN | P07948 | 2/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.53 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.53 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | CCR3 | P51677 | 12/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4087747 | 0.96 | MAPK14 (0.60) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4093523 | 0.93 | MAPK14 (0.64) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4092891 | 0.87 | MAPK14 (0.60) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4464288 | 0.85 | MAPK14 (0.51) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4088671 | 0.84 | MAPK14 (0.67) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4098515 | 0.84 | MAPK14 (0.63) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4096948 | 0.84 | ABL1 (0.68) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4088037 | 0.84 | MAPK14 (0.63) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4096998 | 0.83 | MAPK14 (0.65) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4092250 | 0.83 | MAPK14 (0.72) | MAPK14ABL1RAF1LYNMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116245-A2 | EGFR kinase inhibitor combinations for treating respiratory and gastrointestinal disorders | Boehringer Ingelheim International GmbH (DE) | 2009-11-11 | — | — | EP | disclosed |
| US-20060035893-A1 | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035893-A1 | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders | BDKRB2, EDNRB, GRK5 | MAPK14 74/4885ABL1 1152/4885RAF1 300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.