Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 5/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.33 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4460763 | 0.84 | NOTUM (0.50) | NOTUMLMNACYP1A2POLBMPO | |
| SCHEMBL4464611 | 0.75 | SMN1; SMN2 (0.47) | CA12CA9IGF1RLMNACYP1A2 | |
| SCHEMBL2120922 | 0.71 | NOTUM (0.62) | CA12CA9IGF1RFGFR1KDR | |
| SCHEMBL31434715 | 0.68 | NOTUM (0.62) | CA12CA9NOTUMKDM4ELMNA | |
| SCHEMBL1314692 | 0.68 | NOTUM (0.62) | CA12CA9NOTUMKDM4ELMNA | |
| SCHEMBL9901587 | 0.68 | CA12 (0.49) | CA12CA9IGF1RFGFR1KDR | |
| SCHEMBL8938531 | 0.68 | CA12 (0.49) | CA12CA9NOTUMKDM4ELMNA | |
| SCHEMBL26527466 | 0.68 | CA12 (0.49) | CA12CA9IGF1RFGFR1KDR | |
| SCHEMBL28941884 | 0.67 | CA12 (0.46) | CA12CA9IGF1RFGFR1KDR | |
| SCHEMBL4465981 | 0.67 | NOTUM (0.49) | NOTUMLMNACYP1A2POLBMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |