Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4460763 | 0.85 | NOTUM (0.50) | SMN1; SMN2MAPTNPC1RAB9AL3MBTL1 | |
| SCHEMBL4456076 | 0.77 | ALDH1A1 (0.38) | TDP1ALDH1A1LMNAPOLBHPGD | |
| SCHEMBL4464376 | 0.75 | CA12 (0.38) | SMN1; SMN2MAPTNPC1RAB9AL3MBTL1 | |
| SCHEMBL2898452 | 0.72 | NOTUM (0.64) | SMN1; SMN2MAPTNPC1RAB9AL3MBTL1 | |
| SCHEMBL29914348 | 0.71 | KMT2A (0.39) | SMN1; SMN2MAPTNPC1RAB9AL3MBTL1 | |
| SCHEMBL29914341 | 0.71 | KMT2A (0.41) | SMN1; SMN2MAPTNPC1RAB9AL3MBTL1 | |
| SCHEMBL14591949 | 0.71 | SMN1; SMN2 (0.65) | SMN1; SMN2MAPTNPC1RAB9AL3MBTL1 | |
| SCHEMBL29914351 | 0.70 | KMT2A (0.39) | SMN1; SMN2MAPTNPC1RAB9AL3MBTL1 | |
| SCHEMBL4466620 | 0.70 | TAAR1 (0.43) | KMT2A | |
| SCHEMBL1221306 | 0.70 | MAPT (0.66) | SMN1; SMN2MAPTNPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |