Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.56 |
| ▸ | MST1R | Q04912 | 2/20 | 0.55 |
| ▸ | HGF | P14210 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15405365 | 0.87 | MET (0.54) | METMST1RHGFKDR | |
| SCHEMBL372334 | 0.82 | MET (0.55) | METMST1RHGFKDR | |
| SCHEMBL2866395 | 0.82 | MET (0.56) | METMST1RHGFKDR | |
| SCHEMBL2866269 | 0.81 | MET (0.52) | METMST1RHGFKDR | |
| SCHEMBL13511926 | 0.81 | MET (0.50) | METMST1RHGFKDR | |
| SCHEMBL371933 | 0.79 | MET (0.48) | METMST1RHGFKDR | |
| SCHEMBL2865336 | 0.78 | MET (0.54) | METMST1RHGFKDR | |
| SCHEMBL2861538 | 0.78 | MET (0.55) | METMST1RHGFKDR | |
| SCHEMBL2864470 | 0.77 | MET (0.55) | METMST1RHGFKDR | |
| SCHEMBL371903 | 0.77 | MET (0.60) | METMST1RHGF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |