Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 18/20 | 0.73 |
| ▸ | NR3C2 | P08235 | 13/20 | 0.73 |
| ▸ | PGR | P06401 | 11/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4479076 | 0.92 | NR3C1 (0.67) | NR3C1NR3C2PGR | |
| SCHEMBL4477155 | 0.91 | NR3C1 (0.71) | NR3C1NR3C2PGR | |
| SCHEMBL4477986 | 0.90 | NR3C1 (0.77) | NR3C1NR3C2PGRMAPK1L3MBTL1 | |
| SCHEMBL6228264 | 0.88 | NR3C1 (0.74) | NR3C1NR3C2PGRMAPK1L3MBTL1 | |
| SCHEMBL4470664 | 0.88 | NR3C1 (0.74) | NR3C1NR3C2PGRMAPK1L3MBTL1 | |
| SCHEMBL4479085 | 0.86 | NR3C1 (0.64) | NR3C1NR3C2PGR | |
| SCHEMBL4490262 | 0.85 | NR3C1 (0.80) | NR3C1NR3C2PGR | |
| SCHEMBL293882 | 0.85 | NR3C1 (0.80) | NR3C1NR3C2PGR | |
| SCHEMBL4478823 | 0.85 | NR3C1 (0.71) | NR3C1NR3C2PGRMAPK1L3MBTL1 | |
| SCHEMBL292268 | 0.85 | NR3C1 (1.00) | NR3C1NR3C2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579469-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-08-25 | — | — | US | claimed |
| EP-1583745-A1 | 1-PROPANOL AND 1-PROPYLAMINE DERIVATIVES AND THEIR USE AS GLUCOCORTICOID LIGANDS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-10-12 | — | — | EP | claimed |
| WO-2004063163-A1 | 1-PROPANOL AND 1-PROPYLAMINE DERIVATIVES AND THEIR USE AS GLUCOCORTICOID LIGANDS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-07-29 | — | — | WO | claimed |
| US-7579469-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-08-25 | — | — | US | disclosed |
| US-7579469-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-08-25 | — | — | US | disclosed |
| US-7579469-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-08-25 | — | — | US | disclosed |