Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 20/20 | 0.48 |
| ▸ | GPR183 | P32249 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463566 | 0.86 | GPR119 (0.57) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL4454106 | 0.85 | GPR119 (0.54) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL1128738 | 0.81 | CYP3A4 (0.48) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL2371137 | 0.77 | GPR119 (0.60) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL15110124 | 0.77 | GPR119 (0.50) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL174827 | 0.77 | GPR119 (0.51) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL2370813 | 0.77 | GPR119 (0.51) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL16965423 | 0.76 | GPR119 (0.71) | GPR119GPR183KCNH2 | |
| SCHEMBL13195549 | 0.76 | GPR119 (0.71) | GPR119GPR183KCNH2 | |
| SCHEMBL16965444 | 0.76 | GPR119 (0.71) | GPR119GPR183KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009141238-A1 | GPR119 RECEPTOR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-11-26 | — | — | WO | disclosed |