Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.69 |
| ▸ | ATM | Q13315 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.63 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.53 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.53 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8147403 | 0.90 | KMT2A (0.71) | KMT2AMEN1ATMPOLBKDM4E | |
| SCHEMBL4461930 | 0.89 | POLB (0.61) | KMT2AMEN1ATMPOLBKDM4E | |
| SCHEMBL4470475 | 0.89 | KMT2A (0.77) | KMT2AMEN1ATMPOLBKDM4E | |
| SCHEMBL4474696 | 0.89 | KDM4E (0.61) | KMT2AMEN1ATMPOLBKDM4E | |
| SCHEMBL4475700 | 0.89 | KDM4E (0.59) | KMT2AMEN1ATMPOLBKDM4E | |
| SCHEMBL8136991 | 0.89 | KMT2A (0.85) | KMT2AMEN1ATMPOLBKDM4E | |
| SCHEMBL4459144 | 0.87 | POLB (0.58) | KMT2AMEN1ATMPOLBKDM4E | |
| SCHEMBL4462273 | 0.86 | KDM4E (0.69) | KMT2AMEN1ATMPOLBKDM4E | |
| SCHEMBL4463481 | 0.85 | POLB (0.62) | KMT2AMEN1ATMPOLBKDM4E | |
| SCHEMBL8138323 | 0.85 | POLB (0.72) | KMT2AMEN1ATMPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501512-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-10 | — | — | US | claimed |
| US-20060178384-A1 | 2-(2,6-dimethoxy-phenylamino)-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one; 3-bromo-N-[3-(9-methoxy-4-oxo-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-2-ylamino)-phenyl]-benzamide; kinase inhibitor; neutropenia; cytopenia; anemias | SMITHKLINE BEECHAM CORPORATION | 2006-08-10 | — | — | US | claimed |
| EP-1641766-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-04-05 | — | — | EP | claimed |
| WO-2005007092-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-27 | — | — | WO | claimed |
| US-7501512-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-10 | — | — | US | disclosed |
| US-7501512-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-10 | — | — | US | disclosed |
| US-7501512-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-10 | — | — | US | disclosed |
| US-20060178384-A1 | 2-(2,6-dimethoxy-phenylamino)-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one; 3-bromo-N-[3-(9-methoxy-4-oxo-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-2-ylamino)-phenyl]-benzamide; kinase inhibitor; neutropenia; cytopenia; anemias | SMITHKLINE BEECHAM CORPORATION | 2006-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178384-A1 | 2-(2,6-dimethoxy-phenylamino)-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one; 3-bromo-N-[3-(9-methoxy-4-oxo-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-2-ylamino)-phenyl]-benzamide; kinase inhibitor; neutropenia; cytopenia; anemias | ABL1, MAP3K6, MAP4K2 | KMT2A 473/4885MEN1 2789/4885ATM 326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.