Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | ATM | Q13315 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 5/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.64 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.54 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.54 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.53 |
| ▸ | TSHR | P16473 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8136991 | 0.90 | KMT2A (0.85) | KMT2AMEN1ATMPOLBKDM4E | |
| SCHEMBL4466974 | 0.90 | KMT2A (0.69) | KMT2AMEN1ATMPOLBKDM4E | |
| SCHEMBL17179706 | 0.83 | KMT2A (1.00) | KMT2AMEN1ATMPOLBKDM4E | |
| SCHEMBL8126892 | 0.82 | POLB (1.00) | KMT2AMEN1ATMPOLBKDM4E | |
| SCHEMBL10924611 | 0.81 | POLB (0.80) | KMT2AMEN1ATMPOLBKDM4E | |
| SCHEMBL8128496 | 0.80 | KDM4E (0.70) | KMT2AMEN1ATMPOLBKDM4E | |
| SCHEMBL8146522 | 0.80 | POLB (0.77) | KMT2AMEN1ATMPOLBKDM4E | |
| Hydrochloric Acid SCHEMBL9665606 | 0.80 | POLB (0.77) | KMT2AMEN1ATMPOLBKDM4E | |
| SCHEMBL8140905 | 0.79 | POLB (0.76) | KMT2AMEN1ATMPOLBKDM4E | |
| SCHEMBL4475700 | 0.79 | KDM4E (0.59) | KMT2AMEN1ATMPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973773-A1 | PYRIMIDO-ISOQUINOLINE COMPOUNDS WITH ANTICONVULSIVE ACTION | SMITHKLINE BEECHAM PLC (GB) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998045293-A1 | PYRIMIDO-ISOQUINOLINE COMPOUNDS WITH ANTICONVULSIVE ACTION | SMITHKLINE BEECHAM PLC (GB) | 1998-10-15 | — | — | WO | disclosed |