Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4448421 | 0.81 | GRM2 (0.49) | GRM2KMT2AMEN1RAB9AGAA | |
| SCHEMBL9926818 | 0.76 | TSHR (0.46) | KMT2AMEN1SMN1; SMN2ALDH1A1MAOA | |
| SCHEMBL4467710 | 0.72 | GRM2 (0.46) | GRM2KMT2AEGFRMEN1SMN1; SMN2 | |
| SCHEMBL4447352 | 0.66 | GRM2 (0.37) | GRM2KMT2AMDM2MEN1KDM4E | |
| SCHEMBL9726040 | 0.65 | KDM4E (0.49) | KMT2ASMN1; SMN2KDM4EALDH1A1GAA | |
| SCHEMBL10308932 | 0.65 | KMT2A (0.48) | KMT2ASMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL9151672 | 0.64 | CA1 (0.79) | BACE1SMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL197522 | 0.64 | CA1 (0.79) | BACE1SMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL6733562 | 0.64 | CA1 (0.79) | BACE1SMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL12619209 | 0.64 | SMN1; SMN2 (0.46) | KMT2AMDM2SMN1; SMN2ALDH1A1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137577-A1 | HETEROCYCLIC COMPOUNDS | PFIZER INC. | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137577-A1 | HETEROCYCLIC COMPOUNDS | CYP2D6, ABCG2, CYP2B6 | GRM2 4432/4885KMT2A 3825/4885EGFR 1863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.