Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 3/20 | 0.39 |
| ▸ | BRAF | P15056 | 3/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.37 |
| ▸ | KLRK1 | P26718 | 2/20 | 0.35 |
| ▸ | MICA | Q29983 | 2/20 | 0.35 |
| ▸ | RAET1L | Q5VY80 | 2/20 | 0.35 |
| ▸ | PHGDH | O43175 | 3/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15444400 | 0.83 | RAF1 (0.38) | RAF1BRAFKCNQ2PHGDHMAPK13 | |
| SCHEMBL18482258 | 0.76 | KDM4E (0.41) | RAF1BRAFKCNQ2PHGDH | |
| SCHEMBL40470 | 0.75 | BRAF (0.59) | RAF1BRAFMEN1KMT2A | |
| SCHEMBL44681 | 0.73 | KCNQ2 (0.37) | RAF1BRAFKCNQ2MEN1KMT2A | |
| SCHEMBL46765 | 0.72 | KCNQ2 (0.38) | RAF1BRAFKCNQ2PHGDHMEN1 | |
| SCHEMBL15444401 | 0.72 | MAPT (0.42) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL46775 | 0.72 | MAPK13 (0.42) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL19595872 | 0.72 | ALKBH5 (0.42) | RAF1BRAFKCNQ2 | |
| SCHEMBL39728 | 0.72 | BRAF (0.46) | RAF1BRAFMEN1KMT2AHDAC1 | |
| SCHEMBL39746 | 0.71 | KDM4E (0.47) | RAF1BRAFMEN1KMT2AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| EP-2590656-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |