Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 7/20 | 0.35 |
| ▸ | BRAF | P15056 | 5/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4508137 | 0.78 | MEN1 (0.50) | NR1I2BRAF | |
| SCHEMBL4508141 | 0.76 | ESRRA (0.38) | BRAF | |
| SCHEMBL4559071 | 0.75 | BRAF (0.35) | BRAF | |
| SCHEMBL4465334 | 0.75 | NR1I2 (0.35) | NR1I2BRAF | |
| SCHEMBL4478022 | 0.74 | RXRA (0.37) | NR1I2BRAF | |
| SCHEMBL4466806 | 0.74 | BRAF (0.41) | BRAF | |
| SCHEMBL1404770 | 0.73 | GPBAR1 (0.36) | BRAF | |
| SCHEMBL4501468 | 0.73 | BRAF (0.34) | NR1I2BRAF | |
| SCHEMBL4022025 | 0.72 | NR1H4 (0.46) | NR1I2 | |
| SCHEMBL4462231 | 0.72 | BRAF (0.37) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511042-B2 | 1-[5-(5-tert-Butyl-2-methoxy-3-methylsulfamoyl-phenylcarbamoyl)-2-methyl-phenyl]-1H-1,2,3-triazole-4-carboxylic acid (2,2-dimethyl-propyl)-amide; small molecule cytokine inhibitor; optimized efficacy, pharmacokinetic; antiinflammatory agent, osteoarthritis, asthma, gastrointestinal, respiratory disorder | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-03-31 | — | — | US | claimed |