Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.64 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.64 |
| ▸ | BACE1 | P56817 | 2/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23420347 | 0.89 | EPHX2 (0.54) | EPHX2PRMT6PSMB5CYP2A6CYP3A4 | |
| SCHEMBL2759632 | 0.86 | EPHX2 (0.68) | EPHX2PRMT6BACE1CYP2A6CYP3A4 | |
| SCHEMBL196298 | 0.83 | CTSS (0.51) | PRMT6CTSSCTSK | |
| SCHEMBL30777855 | 0.83 | CTSS (0.51) | PRMT6CTSSCTSK | |
| SCHEMBL1130316 | 0.83 | EPHX2 (0.59) | EPHX2PRMT6BACE1CYP2A6CYP3A4 | |
| SCHEMBL5216350 | 0.83 | CHRNA7 (0.65) | EPHX2PRMT6BACE1CYP2A6CYP3A4 | |
| SCHEMBL1138158 | 0.83 | EPHX2 (0.59) | EPHX2PRMT6BACE1CYP2A6CYP3A4 | |
| SCHEMBL1139185 | 0.83 | EPHX2 (0.59) | EPHX2PRMT6BACE1CYP2A6CYP3A4 | |
| SCHEMBL4490381 | 0.82 | PRKCI (0.62) | EPHX2PRMT6CYP3A4CYP19A1CYP11B1 | |
| SCHEMBL16068455 | 0.82 | CYP2A6 (0.62) | EPHX2PRMT6PSMB5CYP2A6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | JAK2, JAK1, NADK | EPHX2 2126/4885PRMT6 1975/4885BACE1 4379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.