Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.76 |
| ▸ | LMNA | P02545 | 3/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.76 |
| ▸ | HTR1A | P08908 | 11/20 | 0.73 |
| ▸ | DRD2 | P14416 | 7/20 | 0.73 |
| ▸ | HTR2A | P28223 | 4/20 | 0.73 |
| ▸ | HTT | P42858 | 2/20 | 0.73 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | HTR6 | P50406 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.60 |
| ▸ | TDO2 | P48775 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4482017 | 0.90 | KDM4E (0.73) | KDM4ELMNAALOX15HTR1ADRD2 | |
| SCHEMBL4491839 | 0.87 | KDM4E (0.70) | KDM4ELMNAALOX15HTR1ADRD2 | |
| SCHEMBL11321052 | 0.86 | KDM4E (1.00) | KDM4ELMNAALOX15HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL11325899 | 0.86 | KDM4E (1.00) | KDM4ELMNAALOX15HTR1ADRD2 | |
| SCHEMBL11314586 | 0.86 | KDM4E (0.71) | KDM4ELMNAALOX15HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL11327351 | 0.86 | KDM4E (0.71) | KDM4ELMNAALOX15HTR1ADRD2 | |
| SCHEMBL11315106 | 0.84 | KDM4E (0.81) | KDM4ELMNAALOX15HTR1ADRD2 | |
| SCHEMBL11223590 | 0.84 | KDM4E (0.73) | KDM4ELMNAALOX15HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL11313113 | 0.84 | KDM4E (0.81) | KDM4ELMNAALOX15HTR1ADRD2 | |
| SCHEMBL7543848 | 0.84 | HTR1A (1.00) | KDM4ELMNAALOX15HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572808-B2 | Triazolopyridine cannabinoid receptor 1 antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-11 | — | — | US | claimed |
| EP-1891068-A1 | TRIAZOLOPYRIDINE DERIVATIVES AS CANNABINOID RECEPTOR 1 ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2008-02-27 | — | — | EP | claimed |
| US-20070004772-A1 | Triazolopyridine cannabinoid receptor 1 antagonists | BRISTOL-MYERS SQUIBB COMPANY | 2007-01-04 | — | — | US | claimed |
| WO-2006138695-A1 | TRIAZOLOPYRIDINE DERIVATIVES AS CANNABINOID RECEPTOR 1 ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-12-28 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004772-A1 | Triazolopyridine cannabinoid receptor 1 antagonists | CNR1, CNR2, TRPV1 | KDM4E 3120/4885LMNA 4035/4885ALOX15 3290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.