Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.30 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.30 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.30 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.30 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.30 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.30 |
| ▸ | GCGR | P47871 | 1/20 | 0.30 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.30 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.30 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.30 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.30 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4470498 | 0.96 | CYP24A1 (0.32) | CYP24A1MAPT | |
| SCHEMBL3487861 | 0.90 | SMN1; SMN2 (0.35) | CYP24A1MAPTTP53SMN1; SMN2NR1H2 | |
| SCHEMBL3488388 | 0.84 | SMN1; SMN2 (0.35) | MAPTTP53SMN1; SMN2P2RX3NR1H2 | |
| SCHEMBL3487865 | 0.83 | SMN1; SMN2 (0.35) | CYP24A1MAPTTP53SMN1; SMN2 | |
| SCHEMBL3488288 | 0.80 | CA12 (0.41) | MAPTSMN1; SMN2NR1H2NR1H3 | |
| SCHEMBL3488389 | 0.77 | SMN1; SMN2 (0.35) | MAPTTP53SMN1; SMN2P2RX3 | |
| SCHEMBL5322871 | 0.75 | MAPT (0.40) | MAPTSMN1; SMN2P2RX3NR1H2NR1H3 | |
| SCHEMBL5606506 | 0.75 | NR1H2 (0.39) | MAPTTP53SMN1; SMN2P2RX3NR1H2 | |
| SCHEMBL3487236 | 0.74 | MAPT (0.43) | MAPTSMN1; SMN2NR1H2NR1H3 | |
| SCHEMBL3486895 | 0.73 | SMN1; SMN2 (0.38) | MAPTTP53SMN1; SMN2P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582629-B2 | Derivatives of isothiazol-3(2H)-one 1,1-dioxides as liver X receptor modulators | ASTRAZENECA AB (SE) | 2009-09-01 | — | — | US | disclosed |
| US-20080255122-A1 | Derivatives of Isothiazol-3(2H)-One 1,1-Dioxides as Liver X Receptor Modulators | ASTRAZENECA AB (SE) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255122-A1 | Derivatives of Isothiazol-3(2H)-One 1,1-Dioxides as Liver X Receptor Modulators | NR1H2, NR1H3, NR1I2 | CYP24A1 302/4885MAPT 1938/4885KLK7 3958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.