Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ACP1 | P24666 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3488264 | 0.84 | NR1H2 (0.53) | NR1H2NR1H3MAPTSMN1; SMN2THRB | |
| SCHEMBL3487497 | 0.83 | CA12 (0.40) | NR1H2NR1H3 | |
| SCHEMBL3488288 | 0.82 | CA12 (0.41) | NR1H2NR1H3MAPTSMN1; SMN2LMNA | |
| SCHEMBL3487222 | 0.80 | NR1H2 (0.44) | NR1H2NR1H3MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5614062 | 0.79 | NPC1 (0.35) | MAPTLMNANPC1P2RX3 | |
| SCHEMBL5322871 | 0.79 | MAPT (0.40) | NR1H2NR1H3MAPTSMN1; SMN2LMNA | |
| SCHEMBL3488399 | 0.79 | NR1H2 (0.55) | NR1H2NR1H3MAPTSMN1; SMN2LMNA | |
| SCHEMBL5606877 | 0.77 | NR1H2 (0.38) | NR1H2NR1H3MAPTSMN1; SMN2NPC1 | |
| SCHEMBL5614006 | 0.77 | — | — | |
| SCHEMBL3487898 | 0.76 | P2RX3 (0.35) | NR1H2NR1H3MAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838686-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | claimed |
| WO-2006073363-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | claimed |