Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 7/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.45 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | PLD2 | O14939 | 1/20 | 0.42 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494194 | 0.94 | CCR3 (0.43) | CCR3DRD4ADRB2CHRM3SLC5A7 | |
| SCHEMBL4471205 | 0.92 | CCR3 (0.46) | CCR3DRD4ADRB2CHRM3SLC5A7 | |
| SCHEMBL265292 | 0.88 | CHRM3 (0.56) | ADRB2CHRM3 | |
| SCHEMBL4483086 | 0.86 | CHRM3 (0.43) | ADRB2CHRM3SLC5A7CARM1PRMT6 | |
| SCHEMBL4475337 | 0.86 | CHRM3 (0.45) | ADRB2CHRM3SLC5A7CARM1PRMT6 | |
| SCHEMBL4494191 | 0.85 | CHRM2 (0.43) | CCR3DRD4ADRB2CHRM3SLC5A7 | |
| SCHEMBL266252 | 0.83 | CHRM3 (0.51) | ADRB2CHRM3 | |
| SCHEMBL4493969 | 0.83 | CHRM3 (0.40) | ADRB2CHRM3SLC5A7SLC6A2SLC6A4 | |
| SCHEMBL4483296 | 0.83 | CHRM3 (0.45) | ADRB2CHRM3 | |
| SCHEMBL4475461 | 0.83 | CHRM3 (0.46) | ADRB2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632847-B2 | Bronchodilators; treating chronic obstructive pulmonary disease or asthma; long duration of action; reduced side effects, such as dry-mouth and constipation; e.g. biphenyl-2-ylcarbamic acid 1-(2-(3-[3-(4-hydroxybenzylamino)propionylamino]benzoylamino)ethyl)piperidin-4-yl ester | THERAVANCE, INC. (US) | 2009-12-15 | — | — | US | disclosed |