Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 11/20 | 0.59 |
| ▸ | KDR | P35968 | 11/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | PRKAA1 | Q13131 | 9/20 | 0.54 |
| ▸ | PRKAA2 | P54646 | 8/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.52 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.52 |
| ▸ | PLK4 | O00444 | 2/20 | 0.50 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4575835 | 0.82 | PDGFRB (0.62) | PDGFRBKDRFGFR1EGFRPRKAA1 | |
| Trifluoroacetic Acid SCHEMBL2115583 | 0.80 | PDGFRB (0.61) | PDGFRBKDRFGFR1EGFRPRKAA1 | |
| SCHEMBL2113403 | 0.78 | KDR (0.77) | PDGFRBKDRFGFR1EGFRPRKAA1 | |
| SCHEMBL31672512 | 0.78 | KDR (0.77) | PDGFRBKDRFGFR1EGFRPRKAA1 | |
| SCHEMBL31672558 | 0.77 | PDGFRB (0.73) | PDGFRBKDRFGFR1EGFRPRKAA1 | |
| SCHEMBL2116220 | 0.77 | PDGFRB (0.73) | PDGFRBKDRFGFR1EGFRPRKAA1 | |
| Trifluoroacetic Acid SCHEMBL5513610 | 0.77 | KDR (0.37) | PDGFRBKDRFGFR1EGFRPRKAA1 | |
| SCHEMBL2115889 | 0.76 | KDR (0.84) | PDGFRBKDRFGFR1EGFRPRKAA1 | |
| SCHEMBL13755200 | 0.76 | KDR (0.84) | PDGFRBKDRFGFR1EGFRPRKAA1 | |
| SCHEMBL13755224 | 0.76 | PDGFRB (0.81) | PDGFRBKDRFGFR1EGFRPRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572924-B2 | Pyrrole substituted 2-indolinone protein kinase inhibitors | SUGEN, INC. (US) | 2009-08-11 | — | — | US | disclosed |