Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4471368 | 0.77 | PDGFRB (0.59) | KDRPDGFRBPRKAA1PRKAA2FGFR1 | |
| SCHEMBL2342762 | 0.66 | KDR (0.65) | KDRPDGFRBPRKAA1PRKAA2FGFR1 | |
| SCHEMBL4479404 | 0.64 | PDGFRB (0.38) | KDRPDGFRBPRKAA1PRKAA2FGFR1 | |
| SCHEMBL4479409 | 0.64 | PDGFRB (0.38) | KDRPDGFRBPRKAA1PRKAA2FGFR1 | |
| Trifluoroacetic Acid SCHEMBL2115384 | 0.63 | KDR (0.58) | KDRPDGFRBPRKAA1PRKAA2FGFR1 | |
| SCHEMBL5550343 | 0.62 | IDO1 (0.45) | KDRPDGFRBPRKAA1PRKAA2FGFR1 | |
| SCHEMBL4639795 | 0.62 | IDO1 (0.45) | KDRPDGFRBPRKAA1PRKAA2FGFR1 | |
| SCHEMBL13712815 | 0.59 | PDGFRB (0.47) | KDRPDGFRBPRKAA1PRKAA2FGFR1 | |
| SCHEMBL7197592 | 0.58 | TDP1 (0.47) | KDRPDGFRBPRKAA1FGFR1SMN1; SMN2 | |
| SCHEMBL6320390 | 0.58 | GALR3 (0.41) | KDRLMNANTRK1FLT4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010569-A1 | Pyrrole substituted 2-indolinone protein kinase inhibitors | SUGEN, INC. & PHARMACIA & UPJOHN CO. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010569-A1 | Pyrrole substituted 2-indolinone protein kinase inhibitors | PDPK1, PLK2, PNCK | KDR 1387/4885PDGFRB 1034/4885PRKAA1 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.