Sugi Predict

Sugi Predict / Compounds / SCHEMBL4471658

SCHEMBL4471658

SCHEMBL4471658

N#Cc1c(NC2CCCC2)sc(C(=O)c2ccc(Cl)cc2)c1N

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 6/20 0.57
▸ LMNA P02545 3/20 0.53
▸ ALDH1A1 P00352 6/20 0.52
▸ HPGD P15428 3/20 0.52
▸ MEN1 O00255 1/20 0.52
▸ ALOX12 P18054 1/20 0.52
▸ KMT2A Q03164 1/20 0.52
▸ MELK Q14680 7/20 0.52
▸ POLB P06746 1/20 0.52
▸ GAA P10253 2/20 0.51
▸ CYP1A2 P05177 3/20 0.50
▸ CYP2C19 P33261 3/20 0.50
▸ KDM4E B2RXH2 2/20 0.50
▸ CYP3A4 P08684 2/20 0.50
▸ KLK7 P49862 1/20 0.50
▸ HTT P42858 2/20 0.47
▸ MAPK1 P28482 1/20 0.47
▸ SMN1; SMN2 Q16637 2/20 0.44
▸ GALK1 P51570 1/20 0.44
▸ L3MBTL1 Q9Y468 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4475765 0.89 ALDH1A1 (0.65) MAPTLMNAALDH1A1HPGDMEN1
SCHEMBL4470312 0.87 MAPT (0.51) MAPTLMNAALDH1A1HPGDMEN1
SCHEMBL4476324 0.87 ALDH1A1 (0.58) MAPTLMNAALDH1A1HPGDMEN1
SCHEMBL4473330 0.87 MELK (0.70) MAPTLMNAALDH1A1HPGDMEN1
SCHEMBL4473846 0.84 ALDH1A1 (0.55) MAPTLMNAALDH1A1HPGDMEN1
SCHEMBL4487948 0.83 ALDH1A1 (0.47) MAPTLMNAALDH1A1HPGDMEN1
SCHEMBL4488949 0.83 MELK (0.71) MAPTLMNAALDH1A1HPGDMEN1
SCHEMBL4469960 0.83 ALDH1A1 (0.47) MAPTLMNAALDH1A1HPGDMELK
SCHEMBL4473963 0.81 CYP1A2 (0.46) MAPTLMNAALDH1A1HPGDMEN1
SCHEMBL13633822 0.80 ALDH1A1 (0.78) MAPTLMNAALDH1A1HPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-20060041006-A1 PDE4B inhibitors and uses therefor PLEXXIKON, INC. 2006-02-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PDE4B, PDE7B, PDE4A MAPT 3524/4885LMNA 2349/4885ALDH1A1 802/4885
US-20060041006-A1 PDE4B inhibitors and uses therefor PDE4B, PDE7B, PDE4A MAPT 3524/4885LMNA 2349/4885ALDH1A1 802/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.