Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.66 |
| ▸ | KDR | P35968 | 1/20 | 0.66 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.62 |
| ▸ | EGFR | P00533 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4474621 | 1.00 | MET (0.66) | METKDRFGFR2EGFR | |
| Hydrochloric Acid SCHEMBL4473178 | 0.99 | MET (0.65) | METKDRFGFR2EGFR | |
| SCHEMBL4461094 | 0.98 | MET (0.68) | METKDRFGFR2EGFR | |
| SCHEMBL4489534 | 0.98 | MET (0.68) | METKDRFGFR2EGFR | |
| Hydrochloric Acid SCHEMBL4474061 | 0.97 | MET (0.68) | METKDRFGFR2EGFR | |
| SCHEMBL4465009 | 0.96 | FGFR2 (0.68) | METKDRFGFR2EGFR | |
| SCHEMBL4482846 | 0.96 | FGFR2 (0.68) | METKDRFGFR2EGFR | |
| Hydrochloric Acid SCHEMBL4465541 | 0.95 | FGFR2 (0.68) | METKDRFGFR2EGFR | |
| SCHEMBL13936798 | 0.93 | FGFR2 (0.65) | METKDRFGFR2 | |
| SCHEMBL4475887 | 0.93 | PDGFRA (0.59) | METKDRFGFR2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7495104-B2 | Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors | KIRIN BEER KABUSHIKI KAISHA (JP) | 2009-02-24 | — | — | US | claimed |
| US-7495104-B2 | Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors | KIRIN BEER KABUSHIKI KAISHA (JP) | 2009-02-24 | — | — | US | disclosed |
| US-7495104-B2 | Quinoline or quinazoline derivatives inhibiting auto-phosphorylation of fibroblast growth factor receptors | KIRIN BEER KABUSHIKI KAISHA (JP) | 2009-02-24 | — | — | US | disclosed |