Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 11/20 | 1.00 |
| ▸ | KDR | P35968 | 3/20 | 0.64 |
| ▸ | FYN | P06241 | 3/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 3/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.39 |
| ▸ | INSR | P06213 | 3/20 | 0.39 |
| ▸ | LCK | P06239 | 3/20 | 0.39 |
| ▸ | CSF1R | P07333 | 3/20 | 0.39 |
| ▸ | LYN | P07948 | 3/20 | 0.39 |
| ▸ | MET | P08581 | 3/20 | 0.39 |
| ▸ | KIT | P10721 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.39 |
| ▸ | SRC | P12931 | 3/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4474048 | 0.80 | EPHB4 (1.00) | EPHB4KDRBRAF | |
| SCHEMBL3531001 | 0.79 | EPHB4 (0.64) | EPHB4KDRFYNBTKPLK4 | |
| Gw856804X SCHEMBL32678602 | 0.79 | EPHB4 (1.00) | EPHB4KDRFYNPLK4AURKA | |
| Gw856804X SCHEMBL32678600 | 0.79 | EPHB4 (1.00) | EPHB4KDRFYNPLK4AURKA | |
| Gw856804X SCHEMBL4471490 | 0.79 | EPHB4 (1.00) | EPHB4KDRFYNPLK4AURKA | |
| Gw856804X SCHEMBL32678604 | 0.79 | EPHB4 (1.00) | EPHB4KDRFYNPLK4AURKA | |
| SCHEMBL4473618 | 0.77 | EPHB4 (1.00) | EPHB4KDRFYN | |
| SCHEMBL4464897 | 0.77 | EPHB4 (0.70) | EPHB4KDRFYNBTKPLK4 | |
| SCHEMBL4471357 | 0.77 | EPHB4 (1.00) | EPHB4KDRPLK4AURKALCK | |
| SCHEMBL4461110 | 0.76 | EPHB4 (0.71) | EPHB4KDRFYNBTKPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592352-B2 | Substituted thieno and furo-pyridines | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-22 | — | — | US | claimed |
| US-20080182868-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2008-07-31 | — | — | US | claimed |
| JP-2006528685-A | — | — | 2006-12-21 | — | — | JP | claimed |
| EP-1620094-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-02-01 | — | — | EP | claimed |
| WO-2004100947-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-11-25 | — | — | WO | claimed |
| US-7592352-B2 | Substituted thieno and furo-pyridines | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592352-B2 | Substituted thieno and furo-pyridines | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592352-B2 | Substituted thieno and furo-pyridines | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| US-20080182868-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2008-07-31 | — | — | US | disclosed |
| US-20080182868-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2008-07-31 | — | — | US | disclosed |
| US-20080182868-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2008-07-31 | — | — | US | disclosed |
| EP-1620094-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004100947-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080182868-A1 | Novel chemical compounds | HRAS, VHL, TP53 | EPHB4 2484/4885KDR 983/4885FYN 405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.