Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.31 |
| ▸ | MTOR | P42345 | 3/20 | 0.31 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.31 |
| ▸ | NPY1R | P25929 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | VNN1 | O95497 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3810582 | 0.83 | SHMT2 (0.46) | P2RX7SHMT2 | |
| SCHEMBL3815980 | 0.81 | NAMPT (0.42) | SPRP2RX7SYKNAMPTPARP1 | |
| SCHEMBL3820161 | 0.81 | SCD (0.47) | SCDSCD5SPRP2RX7NAMPT | |
| SCHEMBL3817484 | 0.73 | SHMT2 (0.52) | SHMT2 | |
| SCHEMBL3812679 | 0.72 | SHMT2 (0.40) | SHMT2 | |
| SCHEMBL3816976 | 0.71 | NAMPT (0.39) | SPRP2RX7SYKNAMPTPARP1 | |
| SCHEMBL3815730 | 0.71 | SCD (0.44) | SCDSCD5SPRP2RX7SYK | |
| SCHEMBL930779 | 0.70 | GRM5 (0.45) | SHMT2 | |
| SCHEMBL3813227 | 0.70 | SHMT2 (0.44) | SHMT2 | |
| SCHEMBL3812163 | 0.69 | NAMPT (0.39) | SPRP2RX7SYKNAMPTPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |