Sugi Predict

Sugi Predict / Compounds / SCHEMBL4473526

SCHEMBL4473526

SCHEMBL4473526

N#Cc1c(Nc2ccccc2)sc(C(=O)Nc2nccs2)c1N

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.59
▸ MAPT P10636 5/20 0.59
▸ GAA P10253 2/20 0.59
▸ LMNA P02545 4/20 0.54
▸ POLB P06746 2/20 0.54
▸ HPGD P15428 4/20 0.52
▸ HTT P42858 2/20 0.52
▸ MAPK1 P28482 1/20 0.52
▸ NPC1 O15118 6/20 0.48
▸ RAB9A P51151 6/20 0.48
▸ SMN1; SMN2 Q16637 4/20 0.47
▸ AURKA O14965 1/20 0.47
▸ PIM1 P11309 1/20 0.47
▸ CDK2 P24941 1/20 0.47
▸ GSK3B P49841 1/20 0.47
▸ MEN1 O00255 1/20 0.47
▸ ALOX12 P18054 1/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ KCNK3 O14649 1/20 0.47
▸ KCNK9 Q9NPC2 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4465016 0.78 ALDH1A1 (0.78) ALDH1A1MAPTGAALMNAPOLB
SCHEMBL13633821 0.76 ALDH1A1 (0.58) ALDH1A1MAPTGAALMNAPOLB
SCHEMBL632022 0.75 ALDH1A1 (1.00) ALDH1A1MAPTGAALMNAPOLB
SCHEMBL2826317 0.73 NPC1 (0.59) NPC1RAB9AAURKAPIM1CDK2
SCHEMBL3823495 0.72 MAPT (0.68) ALDH1A1MAPTGAALMNAPOLB
SCHEMBL4509612 0.71 ALDH1A1 (0.86) ALDH1A1MAPTGAALMNAPOLB
SCHEMBL4477085 0.70 ALDH1A1 (1.00) ALDH1A1MAPTGAALMNAPOLB
SCHEMBL4465841 0.70 MAPT (0.84) ALDH1A1MAPTGAALMNAPOLB
SCHEMBL4496937 0.69 MAPT (0.80) ALDH1A1MAPTGAALMNAPOLB
SCHEMBL4469348 0.69 ALDH1A1 (0.77) ALDH1A1MAPTGAALMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-20060041006-A1 PDE4B inhibitors and uses therefor PLEXXIKON, INC. 2006-02-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PDE4B, PDE7B, PDE4A ALDH1A1 802/4885MAPT 3524/4885GAA 77/4885
US-20060041006-A1 PDE4B inhibitors and uses therefor PDE4B, PDE7B, PDE4A ALDH1A1 802/4885MAPT 3524/4885GAA 77/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.