Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 11/20 | 0.55 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PKLR | P30613 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4473590 | 0.83 | RORC (0.55) | RORCNR1H3NR1H2KMT2AMEN1 | |
| SCHEMBL2001670 | 0.82 | RORC (0.58) | RORCNR1H3NR1H2KMT2AMEN1 | |
| SCHEMBL2005182 | 0.81 | RORC (0.60) | RORCNR1H3NR1H2KMT2AMEN1 | |
| SCHEMBL12569920 | 0.81 | RORC (0.57) | RORCNR1H3NR1H2PKMALDH1A1 | |
| SCHEMBL2002159 | 0.78 | RORC (0.53) | RORCNR1H3NR1H2KMT2AALDH1A1 | |
| SCHEMBL25166807 | 0.76 | NR1H3 (0.51) | RORCNR1H3NR1H2KMT2AMEN1 | |
| SCHEMBL30231372 | 0.76 | NR1H3 (0.51) | RORCNR1H3NR1H2KMT2AMEN1 | |
| SCHEMBL25246074 | 0.76 | RORC (0.45) | RORCNR1H3NR1H2PKMALDH1A1 | |
| SCHEMBL1999081 | 0.76 | RORC (0.57) | RORCNR1H3NR1H2NR1I2 | |
| SCHEMBL19648360 | 0.76 | RORC (0.64) | RORCKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009120660-A2 | SUBSTITUTED PYRIDOXAZINES | CARA THERAPEUTICS, INC. (US) | 2009-10-01 | — | — | WO | disclosed |