Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 7/20 | 0.68 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8250657 | 0.85 | HCRTR1 (0.72) | HCRTR1HCRTR2ALDH1A1LMNAKMT2A | |
| SCHEMBL8250659 | 0.85 | HCRTR1 (0.69) | HCRTR1HCRTR2ALDH1A1LMNAKMT2A | |
| SCHEMBL13865128 | 0.83 | HCRTR1 (0.64) | HCRTR1HCRTR2ALDH1A1LMNAKMT2A | |
| SCHEMBL13865125 | 0.83 | HCRTR1 (0.69) | HCRTR1HCRTR2ALDH1A1LMNAKMT2A | |
| SCHEMBL4498001 | 0.82 | HCRTR1 (0.68) | HCRTR1HCRTR2ALDH1A1LMNAKMT2A | |
| SCHEMBL30644098 | 0.81 | HCRTR1 (1.00) | HCRTR1HCRTR2ALDH1A1LMNAKMT2A | |
| SCHEMBL4493129 | 0.81 | HCRTR1 (1.00) | HCRTR1HCRTR2ALDH1A1LMNAKMT2A | |
| SCHEMBL4486220 | 0.81 | HCRTR1 (0.66) | HCRTR1HCRTR2ALDH1A1LMNAKMT2A | |
| SCHEMBL2707045 | 0.81 | HCRTR1 (1.00) | HCRTR1HCRTR2ALDH1A1LMNAKMT2A | |
| SCHEMBL4474283 | 0.81 | HCRTR1 (0.67) | HCRTR1HCRTR2ALDH1A1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118200-A1 | Proline bis-amide orexin receptor antagonists | MERCK SHARP & DOHME CORP. | 2009-05-07 | — | — | US | disclosed |
| US-20090118200-A1 | Proline bis-amide orexin receptor antagonists | MERCK SHARP & DOHME CORP. | 2009-05-07 | — | — | US | disclosed |
| US-20090118200-A1 | Proline bis-amide orexin receptor antagonists | MERCK SHARP & DOHME CORP. | 2009-05-07 | — | — | US | disclosed |
| WO-2006127550-A1 | PROLINE BIS-AMIDE OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118200-A1 | Proline bis-amide orexin receptor antagonists | HCRTR1, HCRTR2, NPSR1 | HCRTR1 1/4885HCRTR2 2/4885ALDH1A1 3973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.