Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.54 |
| ▸ | PDE5A | O76074 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24138577 | 0.85 | METAP1 (0.73) | METAP1MAPTALDH1A1POLBKMT2A | |
| SCHEMBL31169377 | 0.79 | METAP1 (0.66) | METAP1MAPTALDH1A1POLBKMT2A | |
| SCHEMBL30394017 | 0.79 | METAP1 (0.66) | METAP1MAPTALDH1A1POLBKMT2A | |
| SCHEMBL10705638 | 0.79 | METAP1 (0.66) | METAP1MAPTALDH1A1POLBKMT2A | |
| SCHEMBL5738982 | 0.78 | METAP1 (0.63) | METAP1MAPTALDH1A1KMT2ARAB9A | |
| SCHEMBL2913642 | 0.78 | METAP1 (0.64) | METAP1MAPTALDH1A1POLBKMT2A | |
| SCHEMBL31716509 | 0.78 | METAP1 (0.63) | METAP1MAPTALDH1A1POLBKMT2A | |
| SCHEMBL24590229 | 0.77 | METAP1 (0.62) | METAP1MAPTALDH1A1POLBKMT2A | |
| SCHEMBL24589753 | 0.77 | METAP1 (0.62) | METAP1MAPTALDH1A1POLBKMT2A | |
| SCHEMBL24590225 | 0.77 | METAP1 (0.62) | METAP1MAPTALDH1A1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014128206-A1 | COMPOUNDS FOR USE IN INHIBITING HIV CAPSID ASSEMBLY | Ruprecht-Karls-Universität Heidelberg (DE) | 2014-08-28 | — | — | WO | disclosed |
| EP-2769723-A1 | Compounds for use in inhibiting HIV capsid assembly | Ruprecht-Karls-Universität Heidelberg (DE) | 2014-08-27 | — | — | EP | disclosed |
| US-8064119-B2 | Display element and driving method thereof | KONICA MINOLTA HOLDINGS, INC. (JP) | 2011-11-22 | — | — | US | disclosed |
| US-8064119-B2 | Display element and driving method thereof | KONICA MINOLTA HOLDINGS, INC. (JP) | 2011-11-22 | — | — | US | disclosed |
| US-20110124649-A1 | INHIBITORS OF HUMAN METHIONINE AMINOPEPTIDASE 1 AND METHODS OF TREATING DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-05-26 | — | — | US | disclosed |
| US-20110124649-A1 | INHIBITORS OF HUMAN METHIONINE AMINOPEPTIDASE 1 AND METHODS OF TREATING DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-05-26 | — | — | US | disclosed |
| US-20110058244-A1 | ELECTROCHROMIC DISPLAY ELEMENT | KONICA MINOLTA HOLDINGS, INC. (JP) | 2011-03-10 | — | — | US | disclosed |
| US-20110058244-A1 | ELECTROCHROMIC DISPLAY ELEMENT | KONICA MINOLTA HOLDINGS, INC. (JP) | 2011-03-10 | — | — | US | disclosed |
| US-20100091352-A1 | DISPLAY ELEMENT AND DRIVING METHOD THEREOF | KONICA MINOLTA HOLDINGS, INC. (JP) | 2010-04-15 | — | — | US | disclosed |
| US-20100091352-A1 | DISPLAY ELEMENT AND DRIVING METHOD THEREOF | KONICA MINOLTA HOLDINGS, INC. (JP) | 2010-04-15 | — | — | US | disclosed |
| US-20020025968-A1 | Method for inhibiting neoplastic cells and related conditions by exposure to 4-aminoquinazoline derivatives | OSI PHARMACEUTICALS, INC. | 2002-02-28 | — | — | US | disclosed |
| EP-0579496-B1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO (JP) | 2001-11-14 | — | — | EP | disclosed |
| US-5508151-A | ENVIRONMENTAL COMPATIBILITY; STABILITY | EASTMAN KODAK COMPANY (US) | 1996-04-16 | — | — | US | disclosed |
| US-5439895-A | Cardiovascular disorders; inhibitor of thromboxane A2 synthetase and cyclic guanosine 3',5'-monophosphate | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-08-08 | — | — | US | disclosed |
| US-5436233-A | Nervous system disorders | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0579496-A1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |
| EP-0135975-B1 | QUINAZOLINE AND ISOQUINOLINE DERIVATIVES | AKZO N.V. (NL) | 1988-09-14 | — | — | EP | disclosed |
| US-4694000-A | Quinazoline and isoquinoline derivatives | AKZO N.V. (NL) | 1987-09-15 | — | — | US | disclosed |
| WO-1985001501-A1 | QUINAZOLINE AND ISOQUINOLINE DERIVATIVES | AKZO N.V. (NL) | 1985-04-11 | — | — | WO | disclosed |
| EP-0135975-A2 | Quinazoline and isoquinoline derivatives | AKZO N.V. (NL) | 1985-04-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020025968-A1 | Method for inhibiting neoplastic cells and related conditions by exposure to 4-aminoquinazoline derivatives | VHL, MCL1, NFATC1 | METAP1 1241/4885MAPT 3912/4885ALDH1A1 1566/4885 |
| US-20110124649-A1 | INHIBITORS OF HUMAN METHIONINE AMINOPEPTIDASE 1 AND METHODS OF TREATING DISORDERS | METAP1, DNPEP, METAP2 | METAP1 1/4885MAPT 1249/4885ALDH1A1 536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.