Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 11/20 | 0.67 |
| ▸ | PDE4A | P27815 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4471631 | 0.91 | GPR84 (0.67) | GPR84PDE4AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL16356954 | 0.88 | GPR84 (0.58) | GPR84PDE4AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL883526 | 0.87 | GPR84 (0.55) | GPR84PDE4AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL4477608 | 0.85 | KDM4E (0.59) | GPR84PDE4AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL4465142 | 0.85 | KDM4E (0.59) | GPR84PDE4AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL4464911 | 0.84 | KDM4E (0.59) | GPR84PDE4AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL4475417 | 0.83 | KDM4E (0.56) | GPR84PDE4AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL4465371 | 0.82 | GPR84 (0.55) | GPR84PDE4AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL8134020 | 0.80 | GPR84 (1.00) | GPR84PDE4AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL877184 | 0.80 | GPR84 (0.51) | GPR84PDE4AKDM4EHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501512-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-10 | — | — | US | claimed |
| US-20060178384-A1 | 2-(2,6-dimethoxy-phenylamino)-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one; 3-bromo-N-[3-(9-methoxy-4-oxo-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-2-ylamino)-phenyl]-benzamide; kinase inhibitor; neutropenia; cytopenia; anemias | SMITHKLINE BEECHAM CORPORATION | 2006-08-10 | — | — | US | claimed |
| EP-1641766-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-04-05 | — | — | EP | claimed |
| WO-2005007092-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-27 | — | — | WO | claimed |
| US-7501512-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-10 | — | — | US | disclosed |
| US-7501512-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-10 | — | — | US | disclosed |
| US-7501512-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-10 | — | — | US | disclosed |
| US-20060178384-A1 | 2-(2,6-dimethoxy-phenylamino)-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one; 3-bromo-N-[3-(9-methoxy-4-oxo-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-2-ylamino)-phenyl]-benzamide; kinase inhibitor; neutropenia; cytopenia; anemias | SMITHKLINE BEECHAM CORPORATION | 2006-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178384-A1 | 2-(2,6-dimethoxy-phenylamino)-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one; 3-bromo-N-[3-(9-methoxy-4-oxo-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-2-ylamino)-phenyl]-benzamide; kinase inhibitor; neutropenia; cytopenia; anemias | ABL1, MAP3K6, MAP4K2 | GPR84 2674/4885PDE4A 1039/4885KDM4E 1095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.