Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GLS | O94925 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4485099 | 0.87 | IDO1 (0.58) | IDO1CYP3A4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL27954179 | 0.84 | IDO1 (0.55) | IDO1CYP3A4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL4404602 | 0.83 | IDO1 (0.54) | IDO1CYP3A4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8586670 | 0.82 | IDO1 (0.53) | IDO1CYP3A4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL3211483 | 0.81 | IDO1 (0.58) | IDO1CYP3A4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL3199392 | 0.81 | IDO1 (0.63) | IDO1CYP3A4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL29471945 | 0.81 | IDO1 (0.58) | IDO1CYP3A4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL15750592 | 0.81 | IDO1 (0.58) | IDO1CYP3A4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL12310548 | 0.80 | CYP3A4 (0.59) | CYP3A4CYP19A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL321086 | 0.80 | AOC2 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | JAK2, JAK1, NADK | IDO1 940/4885CYP3A4 639/4885CYP19A1 1294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.