Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.53 |
| ▸ | PPARD | Q03181 | 6/20 | 0.53 |
| ▸ | PPARA | Q07869 | 6/20 | 0.53 |
| ▸ | HTR6 | P50406 | 12/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | HTR1F | P30939 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13865486 | 0.91 | PPARG (0.48) | PPARGPPARDPPARAHTR6 | |
| SCHEMBL4487054 | 0.90 | PPARG (0.65) | PPARGPPARDPPARAHTR6CYP1A2 | |
| SCHEMBL3035346 | 0.81 | PPARG (0.81) | PPARGPPARDPPARAHTR6HTR1A | |
| SCHEMBL4559260 | 0.81 | PPARG (0.54) | PPARGPPARDPPARAHTR6HTR1A | |
| SCHEMBL4478083 | 0.78 | PPARG (0.55) | PPARGPPARDPPARAHTR6KDM4E | |
| SCHEMBL3020042 | 0.78 | PPARG (0.57) | PPARGPPARDPPARAHTR6HTR1A | |
| SCHEMBL3019379 | 0.77 | PPARG (0.49) | PPARGPPARDPPARAHTR6HTR1A | |
| SCHEMBL3019374 | 0.77 | PPARG (0.49) | PPARGPPARDPPARAHTR6HTR1A | |
| SCHEMBL3035930 | 0.77 | PPARG (0.67) | PPARGPPARDPPARAHTR6HTR1A | |
| SCHEMBL3030224 | 0.75 | PPARG (0.54) | PPARGPPARDPPARAHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531568-B2 | PPAR active compounds | PLEXXIKON, INC. (US) | 2009-05-12 | — | — | US | disclosed |
| US-7531568-B2 | PPAR active compounds | PLEXXIKON, INC. (US) | 2009-05-12 | — | — | US | disclosed |
| EP-1819673-A2 | INDOLE DERIVATIVES FOR USE AS PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006060456-A2 | INDOLE DERIVATIVES FOR USE AS PPAR PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2006-06-08 | — | — | WO | disclosed |
| US-20060116416-A1 | PPAR active compounds | PLEXXIKON, INC | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116416-A1 | PPAR active compounds | PPARG, PPARA, PPARD | PPARG 1/4885PPARD 3/4885PPARA 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.