Cadaverine Tartrate — predicted protein targets

Known targets — ChEMBL curated mechanism

ACHE ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 BCHE CHRM1 CHRM2 CHRM3 CHRM4 CHRNA3 CHRNA4 CHRNB2 CHRNB4 ESR1 ESR2 GABRA1 GABRB1 GABRG2 GBA1 GHSR HRH1 HTR1D HTR2A MAOB OPRD1 OPRK1 OPRM1 SLC6A2 SLC6A3 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 UGCG rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 3)

	gene	UniProt	supporting neighbours	confidence
▸	CALCRL	Q16602	20/20	0.93

▸	RAMP1	O60894	2/20	0.93

▸	CYP3A4	P08684	1/20	0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Cadaverine Tartrate SCHEMBL3879814	1.00	CALCRL (0.93)	CALCRLRAMP1CYP3A4
SCHEMBL3309832	0.96	CALCRL (1.00)	CALCRLRAMP1CYP3A4
SCHEMBL3309829	0.96	CALCRL (1.00)	CALCRLRAMP1CYP3A4
Hydrochloric Acid SCHEMBL3879865	0.95	CALCRL (0.97)	CALCRLRAMP1CYP3A4
Bromide SCHEMBL3882462	0.95	CALCRL (0.97)	CALCRLRAMP1CYP3A4
SCHEMBL3312209	0.94	CALCRL (0.96)	CALCRLRAMP1CYP3A4
SCHEMBL3312218	0.94	CALCRL (0.96)	CALCRLRAMP1CYP3A4
SCHEMBL3310901	0.94	CALCRL (0.95)	CALCRLRAMP1
SCHEMBL4800906	0.93	CALCRL (0.94)	CALCRLRAMP1
SCHEMBL4800893	0.93	CALCRL (0.94)	CALCRLRAMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-7638625-B2	Crystalline compounds	BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE)	2009-12-29	—	—	US	disclosed
US-20080086003-A1	1-[4-amino-3,5-dibromo-N-[[4-(2,3,4,5-tetrahydro-2(1H)-oxo-1,3-benzodiazepin-3-yl)-1-piperidinyl]carbonyl]-D-phenylalanyl]-4-(1-piperidinyl)-piperidine-p-toluenesulphonate or other inorganic organic salts; calcitonin gene related peptide-antagonist; useful for treating headache and migraine	BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE)	2008-04-10	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20080086003-A1	1-[4-amino-3,5-dibromo-N-[[4-(2,3,4,5-tetrahydro-2(1H)-oxo-1,3-benzodiazepin-3-yl)-1-piperidinyl]carbonyl]-D-phenylalanyl]-4-(1-piperidinyl)-piperidine-p-toluenesulphonate or other inorganic organic salts; calcitonin gene related peptide-antagonist; useful for treating headache and migraine	SUCNR1, TRPC1, TRPV1	CALCRL 10/4885RAMP1 629/4885CYP3A4 2589/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.