Sugi Predict

Sugi Predict / Compounds / SCHEMBL4477182

SCHEMBL4477182

SCHEMBL4477182

Cc1ccc(C(=O)c2sc(Nc3ccc(C(=O)NC4CCOC4=O)cc3)c(C#N)c2N)c(C)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 6/20 0.51
▸ ALDH1A1 P00352 4/20 0.51
▸ POLB P06746 3/20 0.51
▸ KMT2A Q03164 3/20 0.47
▸ HPGD P15428 2/20 0.47
▸ MEN1 O00255 2/20 0.47
▸ ALOX12 P18054 1/20 0.47
▸ GAA P10253 1/20 0.44
▸ LMNA P02545 3/20 0.43
▸ MAPK1 P28482 2/20 0.43
▸ HTT P42858 1/20 0.43
▸ RAB9A P51151 1/20 0.41
▸ CYP1A2 P05177 2/20 0.40
▸ CYP3A4 P08684 2/20 0.40
▸ CYP2C19 P33261 2/20 0.40
▸ KDM4E B2RXH2 1/20 0.40
▸ KLK7 P49862 1/20 0.40
▸ MELK Q14680 3/20 0.40
▸ TP53 P04637 1/20 0.38
▸ CYP2D6 P10635 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4468120 0.86 MAPT (0.45) MAPTALDH1A1POLBKMT2AHPGD
SCHEMBL4469147 0.86 ALDH1A1 (0.44) MAPTALDH1A1POLBKMT2AHPGD
SCHEMBL4484007 0.86 ALDH1A1 (0.46) MAPTALDH1A1POLBKMT2AHPGD
SCHEMBL4468052 0.85 MAPT (0.48) MAPTALDH1A1POLBKMT2AHPGD
SCHEMBL4472094 0.83 MAPT (0.51) MAPTALDH1A1POLBKMT2AHPGD
SCHEMBL4475799 0.82 ALDH1A1 (0.47) MAPTALDH1A1POLBKMT2AHPGD
SCHEMBL4474220 0.82 MAPT (0.46) MAPTALDH1A1POLBKMT2AHPGD
SCHEMBL4476805 0.82 MAPT (0.46) MAPTALDH1A1POLBKMT2AHPGD
SCHEMBL4471831 0.81 MAPT (0.48) MAPTALDH1A1POLBKMT2AHPGD
SCHEMBL4496773 0.81 KMT2A (0.48) MAPTALDH1A1POLBKMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-20060041006-A1 PDE4B inhibitors and uses therefor PLEXXIKON, INC. 2006-02-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PDE4B, PDE7B, PDE4A MAPT 3524/4885ALDH1A1 802/4885POLB 248/4885
US-20060041006-A1 PDE4B inhibitors and uses therefor PDE4B, PDE7B, PDE4A MAPT 3524/4885ALDH1A1 802/4885POLB 248/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.