Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | RXRB | P28702 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12869150 | 0.82 | SMN1; SMN2 (0.55) | SMN1; SMN2 | |
| SCHEMBL14220752 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2GAAHTTTRPM8NPC1 | |
| SCHEMBL1958617 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2RAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL11513846 | 0.81 | PLA2G4A (0.56) | SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL4487061 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2RAB9ANPC1MAPK1 | |
| SCHEMBL9749821 | 0.80 | SMN1; SMN2 (0.65) | SMN1; SMN2TRPM8KDM4EALDH1A1TP53 | |
| SCHEMBL2213142 | 0.80 | SMN1; SMN2 (0.65) | SMN1; SMN2RAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL3845636 | 0.80 | SMN1; SMN2 (0.65) | SMN1; SMN2RAB9ANPC1RXRARXRB | |
| SCHEMBL8320409 | 0.80 | SMN1; SMN2 (0.65) | SMN1; SMN2RAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL27165343 | 0.80 | SMN1; SMN2 (0.65) | SMN1; SMN2ALPLKDM4EALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | JAK2, JAK1, NADK | SMN1; SMN2 3820/4885GAA 2424/4885HTT 1328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.