Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.38 |
| ▸ | RELA | Q04206 | 3/20 | 0.38 |
| ▸ | FOS | P01100 | 1/20 | 0.38 |
| ▸ | JUN | P05412 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3517898 | 0.84 | FASN (0.42) | MAPTPOLBKMT2AMEN1NPC1 | |
| SCHEMBL3514831 | 0.82 | SMN1; SMN2 (0.46) | MAPTPOLBKMT2AKDM4EMEN1 | |
| SCHEMBL3544652 | 0.74 | KDM4E (0.42) | MAPTKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL3516064 | 0.72 | MAOB (0.42) | MAPTPOLBKMT2AKDM4EMEN1 | |
| SCHEMBL3514409 | 0.72 | MAOB (0.47) | MAPTPOLBKMT2AKDM4EMEN1 | |
| SCHEMBL3517692 | 0.71 | KDM4E (0.47) | MAPTKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL3519161 | 0.71 | ALDH1A1 (0.38) | MAPTKMT2AKDM4EALDH1A1TSHR | |
| SCHEMBL3517053 | 0.70 | MAPK8 (0.39) | KMT2AKDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL3516535 | 0.70 | ALDH1A1 (0.38) | MAPTPOLBKMT2AKDM4EMEN1 | |
| SCHEMBL3516982 | 0.69 | KDM4E (0.47) | MAPTKMT2AKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044068-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | Merck & Co., Inc. (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008010964-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK & CO., INC. (US) | 2008-01-24 | — | — | WO | disclosed |