Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 19/20 | 0.60 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4493951 | 0.87 | GSK3B (0.64) | GSK3BAAK1CYP1A2 | |
| SCHEMBL4483526 | 0.85 | GSK3B (0.81) | GSK3BCYP1A2 | |
| SCHEMBL4491518 | 0.85 | GSK3B (0.54) | GSK3B | |
| SCHEMBL4494393 | 0.83 | GSK3B (0.68) | GSK3BAAK1 | |
| SCHEMBL4477055 | 0.83 | GSK3B (0.65) | GSK3BAAK1 | |
| SCHEMBL4480686 | 0.83 | GSK3B (0.65) | GSK3BCYP1A2 | |
| SCHEMBL4491027 | 0.82 | GSK3B (0.69) | GSK3BAAK1CYP1A2 | |
| SCHEMBL4482280 | 0.82 | AAK1 (0.58) | GSK3BAAK1 | |
| SCHEMBL4479295 | 0.82 | GSK3B (0.53) | GSK3B | |
| SCHEMBL4487193 | 0.82 | AAK1 (0.64) | GSK3BAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |