Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.58 |
| ▸ | GSK3A | P49840 | 3/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4497666 | 0.89 | GSK3B (0.69) | GSK3BCYP1A2AAK1GSK3A | |
| SCHEMBL4494393 | 0.89 | GSK3B (0.68) | GSK3BAAK1GSK3APIK3CDPIM1 | |
| SCHEMBL4477055 | 0.89 | GSK3B (0.65) | GSK3BAAK1GSK3APIK3CDPIM1 | |
| SCHEMBL4482280 | 0.88 | AAK1 (0.58) | GSK3BAAK1GSK3APIK3CDPIM1 | |
| SCHEMBL4494613 | 0.87 | GSK3B (0.57) | GSK3BCYP1A2AAK1GSK3ADYRK1A | |
| SCHEMBL4481457 | 0.87 | GSK3B (0.69) | GSK3BCYP1A2AAK1GSK3ADYRK1A | |
| SCHEMBL4494686 | 0.86 | AAK1 (0.57) | GSK3BAAK1GSK3APIK3CDPIM1 | |
| SCHEMBL4502227 | 0.86 | HDAC6 (0.55) | GSK3BCYP1A2AAK1GSK3ADYRK1A | |
| SCHEMBL4491401 | 0.86 | GSK3B (0.73) | GSK3BCYP1A2AAK1GSK3ADYRK1A | |
| SCHEMBL4489254 | 0.85 | HDAC6 (0.67) | GSK3BAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |