Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 2/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9588334 | 0.86 | PARP10 (0.47) | TDP1L3MBTL1PARP10PARP1MALT1 | |
| SCHEMBL1572850 | 0.82 | TDP1 (0.46) | TDP1L3MBTL1PARP10PARP1MALT1 | |
| SCHEMBL30676574 | 0.82 | TDP1 (0.46) | TDP1L3MBTL1PARP10PARP1MALT1 | |
| SCHEMBL16622009 | 0.81 | TDP1 (0.53) | TDP1L3MBTL1PARP10PARP1CA1 | |
| SCHEMBL449033 | 0.79 | TDP1 (0.44) | TDP1L3MBTL1PARP10PARP1MALT1 | |
| SCHEMBL27463810 | 0.79 | CA9 (0.41) | TDP1PARP1CA9TYMSTDP2 | |
| SCHEMBL8779101 | 0.78 | TDP1 (0.50) | TDP1L3MBTL1PARP10PARP1CA1 | |
| SCHEMBL16622013 | 0.78 | TDP1 (0.50) | TDP1L3MBTL1PARP10PARP1CA1 | |
| SCHEMBL1702746 | 0.78 | TDP1 (0.46) | TDP1L3MBTL1PARP10PARP1MALT1 | |
| SCHEMBL2819403 | 0.77 | SMN1; SMN2 (0.51) | MALT1CA1CA2CA4CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041734-B1 | DERIVATIVES HAVING 1,2,3,4-TETRAHYDRONAPHTHALENE MOIETY OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | YUHAN CORP (KR) | 2024-04-24 | — | — | EP | disclosed |
| CN-114746422-B | Derivatives having 1,2,3, 4-tetrahydronaphthalene moiety or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the same | 柳韩洋行 | 2024-03-12 | — | — | CN | disclosed |
| US-11569460-B2 | Organometallic compound, organic light-emitting device including organometallic compound, and diagnostic composition including organometallic compound | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2023-01-31 | — | — | US | disclosed |
| US-20220402909-A1 | NOVEL DERIVATIVES HAVING 1,2,3,4-TETRAHYDRONAPHTHALENE MOIETY OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | YUHAN CORPORATION (KR) | 2022-12-22 | — | — | US | disclosed |
| EP-4041734-A1 | NOVEL DERIVATIVES HAVING 1,2,3,4-TETRAHYDRONAPHTHALENE MOIETY OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | Yuhan Corporation (KR) | 2022-08-17 | — | — | EP | disclosed |
| CN-114746422-A | Novel derivatives having 1,2,3, 4-tetrahydronaphthalene moiety or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the same | 柳韩洋行 | 2022-07-12 | — | — | CN | disclosed |
| EP-3483170-B1 | ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING ORGANOMETALLIC COMPOUND, AND DIAGNOSTIC COMPOSITION INCLUDING ORGANOMETALLIC COMPOUND | SAMSUNG ELECTRONICS CO LTD (KR) | 2021-06-02 | — | — | EP | disclosed |
| WO-2021096239-A1 | NOVEL DERIVATIVES HAVING 1,2,3,4-TETRAHYDRONAPHTHALENE MOIETY OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | YUHAN CORPORATION (KR) | 2021-05-20 | — | — | WO | disclosed |
| EP-3483170-A1 | ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING ORGANOMETALLIC COMPOUND, AND DIAGNOSTIC COMPOSITION INCLUDING ORGANOMETALLIC COMPOUND | Samsung Electronics Co., Ltd. (KR) | 2019-05-15 | — | — | EP | disclosed |
| US-20190140192-A1 | ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING ORGANOMETALLIC COMPOUND, AND DIAGNOSTIC COMPOSITION INCLUDING ORGANOMETALLIC COMPOUND | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2019-05-09 | — | — | US | disclosed |
| WO-2011123674-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-06 | — | — | WO | disclosed |
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| US-20100197711-A1 | BENZOTHIAZOLE COMPOUNDS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2010-08-05 | — | — | US | disclosed |
| EP-2193127-A1 | BENZOTHIAZOLE COMPOUNDS | The Walter and Eliza Hall Institute of Medical Research (AU) | 2010-06-09 | — | — | EP | disclosed |
| WO-2009039553-A1 | BENZOTHIAZOLE COMPOUNDS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2009-04-02 | — | — | WO | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |
| US-5272170-A | Tetralones with pharmacological activity | J. URIACH & CIA., S.A. (ES) | 1993-12-21 | — | — | US | disclosed |
| US-5208246-A | Hypotensive, bronchodilator | J. URIACH & CIA. (ES) | 1993-05-04 | — | — | US | disclosed |
| EP-0525768-A1 | Tetralones with pharmacological activity | J. URIACH & CIA. S.A. (ES) | 1993-02-03 | — | — | EP | disclosed |
| EP-0489300-A2 | Tetralones with pharmacological activity | J. URIACH & CIA. S.A. (ES) | 1992-06-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197711-A1 | BENZOTHIAZOLE COMPOUNDS | BAD, BCL2, BAX | TDP1 1145/4885L3MBTL1 78/4885PARP10 483/4885 |
| US-20220402909-A1 | NOVEL DERIVATIVES HAVING 1,2,3,4-TETRAHYDRONAPHTHALENE MOIETY OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | GBA1, GBA2, GALC | TDP1 1425/4885L3MBTL1 3612/4885PARP10 2683/4885 |
| US-20190140192-A1 | ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING ORGANOMETALLIC COMPOUND, AND DIAGNOSTIC COMPOSITION INCLUDING ORGANOMETALLIC COMPOUND | L1CAM, L3MBTL1, MSL1 | TDP1 2689/4885L3MBTL1 2/4885PARP10 1887/4885 |
| US-11569460-B2 | Organometallic compound, organic light-emitting device including organometallic compound, and diagnostic composition including organometallic compound | L1CAM, L3MBTL1, MSL1 | TDP1 2689/4885L3MBTL1 2/4885PARP10 1887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.