Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 4/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6029000 | 1.00 | MAPT (0.56) | MAPTALDH1A1KDM4ESMN1; SMN2EGFR | |
| SCHEMBL6028998 | 1.00 | MAPT (0.56) | MAPTALDH1A1KDM4ESMN1; SMN2EGFR | |
| SCHEMBL4479980 | 1.00 | MAPT (0.56) | MAPTALDH1A1KDM4ESMN1; SMN2EGFR | |
| SCHEMBL13678130 | 0.87 | MAPT (0.53) | MAPTALDH1A1KDM4ESMN1; SMN2EGFR | |
| SCHEMBL9364774 | 0.82 | MAPT (0.56) | MAPTALDH1A1KDM4ESMN1; SMN2EGFR | |
| SCHEMBL9364776 | 0.82 | MAPT (0.56) | MAPTALDH1A1KDM4ESMN1; SMN2EGFR | |
| SCHEMBL11450460 | 0.79 | APP (0.61) | MAPTALDH1A1KDM4ESMN1; SMN2EGFR | |
| SCHEMBL11450459 | 0.79 | APP (0.61) | MAPTALDH1A1KDM4ESMN1; SMN2EGFR | |
| SCHEMBL9362093 | 0.77 | APP (0.59) | MAPTALDH1A1KDM4ESMN1; SMN2EGFR | |
| SCHEMBL9362086 | 0.77 | APP (0.59) | MAPTALDH1A1KDM4ESMN1; SMN2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272457-B9 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RES DEV LP (CA) | 2006-12-20 | — | — | EP | claimed |
| EP-1272457-B1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RES DEV LP (CA) | 2006-08-23 | — | — | EP | claimed |
| US-7012095-B2 | Compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED (CA) | 2006-03-14 | — | — | US | claimed |
| US-20040209845-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2004-10-21 | — | — | US | claimed |
| US-20040072803-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED (CA) | 2004-04-15 | — | — | US | claimed |
| JP-2003531133-A | — | — | 2003-10-21 | — | — | JP | claimed |
| US-20030109502-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2003-06-12 | — | — | US | claimed |
| EP-1272457-A2 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC Research and Development Limited Partnership (CA) | 2003-01-08 | — | — | EP | claimed |
| WO-2001079158-A2 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2001-10-25 | — | — | WO | claimed |
| US-7598419-B2 | Compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2009-10-06 | — | — | US | disclosed |
| US-20070243612-A1 | Novel Compounds for Modulating Cell Proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2007-10-18 | — | — | US | disclosed |
| EP-1752446-A2 | Compounds for modulating cell proliferation | HSC Research and Development Limited Partnership (CA) | 2007-02-14 | — | — | EP | disclosed |
| EP-1272457-B9 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RES DEV LP (CA) | 2006-12-20 | — | — | EP | disclosed |
| US-20060241084-A1 | Inhibition of vascular endothelial growth factor | THE HOSPITAL FOR SICK CHILDREN (CA) | 2006-10-26 | — | — | US | disclosed |
| US-20040209845-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2004-10-21 | — | — | US | disclosed |
| US-6800659-B2 | NOVEL STYRYLACRYLONITRILE COMPOUNDS WHICH ARE USEFUL IN TREATING A VARIETY OF CELL PROLIFERATIVE DISORDERS SUCH AS CANCER ARE DISCLOSED. A METHOD OF MODULATING CELL PROLIFERATION COMPRISING ADMINISTERING AN EFFECTIVE AMOUNT OF | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2004-10-05 | — | — | US | disclosed |
| US-20040072803-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED (CA) | 2004-04-15 | — | — | US | disclosed |
| US-20030109502-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2003-06-12 | — | — | US | disclosed |
| EP-1272457-A2 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC Research and Development Limited Partnership (CA) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001079158-A2 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2001-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241084-A1 | Inhibition of vascular endothelial growth factor | VEGFA, FLT4, FLT1 | MAPT 3009/4885ALDH1A1 330/4885KDM4E 3163/4885 |
| US-20070243612-A1 | Novel Compounds for Modulating Cell Proliferation | MKI67, CCNA1, PCNA | MAPT 4784/4885ALDH1A1 546/4885KDM4E 3095/4885 |
| US-20040209845-A1 | Novel compounds for modulating cell proliferation | MKI67, CCNA1, CCNI | MAPT 4740/4885ALDH1A1 178/4885KDM4E 3326/4885 |
| US-20030109502-A1 | Novel compounds for modulating cell proliferation | MKI67, CCNA1, CCNI | MAPT 4740/4885ALDH1A1 178/4885KDM4E 3326/4885 |
| US-20040072803-A1 | Novel compounds for modulating cell proliferation | MKI67, CCNA1, MCL1 | MAPT 4762/4885ALDH1A1 179/4885KDM4E 3230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.