Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.44 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4467899 | 0.92 | MAPT (0.54) | MAPTL3MBTL1SMN1; SMN2MEN1HTT | |
| SCHEMBL4378804 | 0.87 | MAPK14 (0.56) | MAPTL3MBTL1SMN1; SMN2MEN1HTT | |
| SCHEMBL4385079 | 0.87 | MAPK14 (0.51) | MAPTL3MBTL1SMN1; SMN2MEN1HTT | |
| SCHEMBL4476536 | 0.86 | MAPK14 (0.55) | MAPTL3MBTL1SMN1; SMN2MEN1HTT | |
| SCHEMBL4466743 | 0.82 | MAPK14 (0.60) | MAPTL3MBTL1SMN1; SMN2MEN1HTT | |
| SCHEMBL3521684 | 0.82 | MAPT (0.48) | MAPTL3MBTL1SMN1; SMN2MEN1HTT | |
| SCHEMBL4376114 | 0.79 | MAPK14 (0.64) | MAPTL3MBTL1SMN1; SMN2MEN1HTT | |
| SCHEMBL4474073 | 0.78 | MAPK14 (0.57) | L3MBTL1SMN1; SMN2MEN1KMT2AMAPK14 | |
| SCHEMBL4478413 | 0.77 | MAPK14 (0.56) | MAPTL3MBTL1SMN1; SMN2MEN1HTT | |
| SCHEMBL4389631 | 0.76 | ALDH1A1 (0.55) | L3MBTL1SMN1; SMN2MEN1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040058964-A1 | Substituted pyridinones | PHARMACIA LLC | 2004-03-25 | — | — | US | claimed |
| US-7629363-B2 | antiinflammatory agent for treating asthma and chronic pulmonary inflammatory disease | PFIZER INC (US) | 2009-12-08 | — | — | US | disclosed |
| US-7067540-B2 | Substituted pyridinones | PHARMACIA CORPORATION (US) | 2006-06-27 | — | — | US | disclosed |
| US-20050176775-A1 | Substituted pyridinones | PHARMACIA CORPORATION | 2005-08-11 | — | — | US | disclosed |
| WO-2005018557-A2 | SUBSTITUTED PYRIDINONES | PHARMACIA CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |
| US-20040058964-A1 | Substituted pyridinones | PHARMACIA LLC | 2004-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058964-A1 | Substituted pyridinones | MAPK1, MAPK6, MAPK7 | MAPT 2803/4885L3MBTL1 3937/4885SMN1; SMN2 1433/4885 |
| US-20050176775-A1 | Substituted pyridinones | MAPK1, MAPK6, MAP3K6 | MAPT 2543/4885L3MBTL1 3850/4885SMN1; SMN2 1419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.